4wzx
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins== |
| - | + | <StructureSection load='4wzx' size='340' side='right' caption='[[4wzx]], [[Resolution|resolution]] 1.39Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4wzx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WZX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WZX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wzx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wzx RCSB], [http://www.ebi.ac.uk/pdbsum/4wzx PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/ULK3_HUMAN ULK3_HUMAN]] Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.<ref>PMID:19279323</ref> <ref>PMID:19878745</ref> <ref>PMID:20643644</ref> [[http://www.uniprot.org/uniprot/IST1_HUMAN IST1_HUMAN]] Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.<ref>PMID:19129479</ref> <ref>PMID:19129480</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Non-specific serine/threonine protein kinase]] | ||
| + | [[Category: Agromayor, M]] | ||
| + | [[Category: Alam, S L]] | ||
| + | [[Category: Caballe, A]] | ||
| + | [[Category: Carlton, J G]] | ||
[[Category: Kloc, M]] | [[Category: Kloc, M]] | ||
| - | [[Category: Skalicky, J.J]] | ||
| - | [[Category: Carlton, J.G]] | ||
| - | [[Category: Alam, S.L]] | ||
[[Category: Labrador, L]] | [[Category: Labrador, L]] | ||
| - | [[Category: | + | [[Category: Martin-Serrano, J]] |
| + | [[Category: Skalicky, J J]] | ||
| + | [[Category: Sundquist, W I]] | ||
| + | [[Category: Wenzel, D M]] | ||
| + | [[Category: Cell cycle]] | ||
| + | [[Category: Escrt]] | ||
| + | [[Category: Ist1]] | ||
| + | [[Category: Mim]] | ||
| + | [[Category: Mit domain]] | ||
| + | [[Category: Ulk3]] | ||
Revision as of 12:44, 3 June 2015
ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins
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