4s1y

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'''Unreleased structure'''
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==X-ray structure of human serum albumin complexed with cisplatin==
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<StructureSection load='4s1y' size='340' side='right' caption='[[4s1y]], [[Resolution|resolution]] 3.16&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4s1y]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S1Y FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hk1|1hk1]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4s1y RCSB], [http://www.ebi.ac.uk/pdbsum/4s1y PDBsum]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for the first time. Structural data unambiguously prove that cisplatin mainly binds to His105 and Met329 side chains; additional binding sites are detected at His288, Met298, and Met548 and at His535, His67 and His247.
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The entry 4s1y is ON HOLD until Paper Publication
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Cisplatin binding to human serum albumin: a structural study.,Ferraro G, Massai L, Messori L, Merlino A Chem Commun (Camb). 2015 Apr 15. PMID:25873085<ref>PMID:25873085</ref>
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Authors: Merlino, A.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description: X-ray structure of human serum albumin complexed with cisplatin
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Merlino, A]]
[[Category: Merlino, A]]
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[[Category: Albumin]]
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[[Category: Drug transport]]
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[[Category: Fatty acid]]
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[[Category: Transport protein]]

Revision as of 11:34, 30 April 2015

X-ray structure of human serum albumin complexed with cisplatin

4s1y, resolution 3.16Å

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