4xfz

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'''Unreleased structure'''
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==Structure of the native full-length HIV-1 capsid protein in complex with PF-3450074 (PF74)==
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<StructureSection load='4xfz' size='340' side='right' caption='[[4xfz]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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The entry 4xfz is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4xfz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XFZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XFZ FirstGlance]. <br>
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Authors: Gres, A.T., Kirby, K.A., Sarafianos, S.G.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1B0:N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE'>1B0</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xfx|4xfx]], [[4xfy|4xfy]]</td></tr>
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Description:
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xfz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xfz RCSB], [http://www.ebi.ac.uk/pdbsum/4xfz PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Sarafianos, S.G]]
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== Function ==
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[[Category: Kirby, K.A]]
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[[http://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5]] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
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[[Category: Gres, A.T]]
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__TOC__
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</StructureSection>
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[[Category: Gres, A T]]
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[[Category: Kirby, K A]]
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[[Category: Sarafianos, S G]]
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[[Category: Antiviral]]
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[[Category: Capsid protein]]
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[[Category: Complex]]
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[[Category: Pf-3450074]]
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[[Category: Pf74]]

Revision as of 14:09, 10 June 2015

Structure of the native full-length HIV-1 capsid protein in complex with PF-3450074 (PF74)

4xfz, resolution 2.70Å

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