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(Difference between revisions)
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<StructureSection load='Uba1.pdb' size='340' side='right' caption='Caption for this structure' scene='69/695713/Uba1/1'> | <StructureSection load='Uba1.pdb' size='340' side='right' caption='Caption for this structure' scene='69/695713/Uba1/1'> | ||
| - | <scene name='69/695713/Uba1/1'>Opener</scene> | ||
<scene name='69/695713/Uba1/6'>Show dimer</scene> | <scene name='69/695713/Uba1/6'>Show dimer</scene> | ||
<scene name='69/695713/Uba1/7'>where Ub</scene> | <scene name='69/695713/Uba1/7'>where Ub</scene> | ||
| - | <scene name='69/695713/Uba1_monomeric_ub/2'>monomer +ub</scene> | ||
| - | <scene name='69/695713/Uba1_monomeric_ub_catcys_hi/1'>Cat Cys+ub</scene> | ||
== Function == | == Function == | ||
UBA1's place in the Ubiquitination process, E1 what that means etc. | UBA1's place in the Ubiquitination process, E1 what that means etc. | ||
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== Structural highlights == | == Structural highlights == | ||
overall structure, bound structure, monomer, active site catalytic residues. | overall structure, bound structure, monomer, active site catalytic residues. | ||
| + | The <scene name='69/695713/Uba1/1'>monomeric structure</scene> of Uba1 consists of six structural domains (IAD, AAD, FCCH, SCCH, 4HB, and UFD), four of which pack together to create a central canyon.{Lee, 2008} The canyon is divided into two distinct clefts (left and right) by the SCCH/AAD linker fragment.{Lee, 2008} Ubiquitin binds to the cysteine located on the right cleft of Uba1 which allows for Ubiquitin to orient itself relative to the active site located on the left cleft.{Lee, 2008} The structure of <scene name='69/695713/Uba1_monomeric_ub/2'>Ubiquitin bound to Uba1</scene> results in a change in conformation that buries a significant portion of Uba1 exposed surface area.{Lee, 2008} | ||
== References == | == References == | ||
Revision as of 20:04, 24 February 2015
UBA1
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