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The <scene name='69/695713/Uba1/1'>monomeric structure</scene> of Uba1 consists of six structural domains (IAD, AAD, FCCH, SCCH, 4HB, and UFD), four of which pack together to create a central canyon.{Lee, 2008} The canyon is divided into two distinct clefts (left and right) by the SCCH/AAD linker fragment.{Lee, 2008} Ubiquitin binds to the cysteine located on the right cleft of Uba1 which allows for Ubiquitin to orient itself relative to the active site located on the left cleft.{Lee, 2008} The structure of <scene name='69/695713/Uba1_monomeric_ub/2'>Ubiquitin bound to Uba1</scene> results in a change in conformation that buries a significant portion of Uba1 exposed surface area.{Lee, 2008} | The <scene name='69/695713/Uba1/1'>monomeric structure</scene> of Uba1 consists of six structural domains (IAD, AAD, FCCH, SCCH, 4HB, and UFD), four of which pack together to create a central canyon.{Lee, 2008} The canyon is divided into two distinct clefts (left and right) by the SCCH/AAD linker fragment.{Lee, 2008} Ubiquitin binds to the cysteine located on the right cleft of Uba1 which allows for Ubiquitin to orient itself relative to the active site located on the left cleft.{Lee, 2008} The structure of <scene name='69/695713/Uba1_monomeric_ub/2'>Ubiquitin bound to Uba1</scene> results in a change in conformation that buries a significant portion of Uba1 exposed surface area.{Lee, 2008} | ||
== References == | == References == | ||
Revision as of 20:19, 24 February 2015
UBA1
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