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Background

Cocaine Esterase (CocE) is the most efficient protein to hydrolyze the cocaine domain known to date in vivo.^[3] Cocaine Esterase is used in bacterium Rhodococcus which hydrolyzes the cocaine that it uptakes and uses it for carbons and nitrogens. Although this protein metabolizes cocaine in bacterium, it is sure to induce an immune response as it is foreign to the human body. This could mitigate the effects of CocE if a person had suffered from cocaine toxicity.

Structure

Cocaine Esterase is a globular protein that is expressed in the cytosol of Rhodococcus strain of bacteria, containing 574 residues divided into three domains.

Function

Cocaine esterase is used to catalyze the following reaction: cocaine + H₂O ←→ ecgonine methyl ester + benzoate ^[4] Reaction mechanism for cocaine esterase-catalyzed hydrolyses of (+)- and (-)-cocaine: unexpected common rate-determining step. Liu J1, Zhao X, Yang W, Zhan CG.

Medical Relevance

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