4p2y

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'''Unreleased structure'''
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==Crystal structure of the human RAGE ectodomain (fragment VC1C2) in complex with mouse S100A6==
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<StructureSection load='4p2y' size='340' side='right' caption='[[4p2y]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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The entry 4p2y is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4p2y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P2Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P2Y FirstGlance]. <br>
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Authors: Yatime, L., Andersen, G.R.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lp5|4lp5]], [[4lp4|4lp4]]</td></tr>
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Description: Crystal structure of the human RAGE ectodomain (fragment VC1C2) in complex with mouse S100A6
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p2y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p2y RCSB], [http://www.ebi.ac.uk/pdbsum/4p2y PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Andersen, G.R]]
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== Function ==
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[[http://www.uniprot.org/uniprot/RAGE_HUMAN RAGE_HUMAN]] Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.<ref>PMID:19906677</ref> [[http://www.uniprot.org/uniprot/S10A6_MOUSE S10A6_MOUSE]] May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Andersen, G R]]
[[Category: Yatime, L]]
[[Category: Yatime, L]]
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[[Category: Dimerization]]
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[[Category: Ef-hand calcium binding protein]]
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[[Category: Pattern recognition receptor]]
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[[Category: Signaling complex]]
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[[Category: Signaling protein]]

Revision as of 11:53, 11 March 2015

Crystal structure of the human RAGE ectodomain (fragment VC1C2) in complex with mouse S100A6

4p2y, resolution 2.30Å

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