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4y1s

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'''Unreleased structure'''
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==Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes==
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<StructureSection load='4y1s' size='340' side='right' caption='[[4y1s]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
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The entry 4y1s is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4y1s]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y1S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y1S FirstGlance]. <br>
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Authors: Conroy, P.J., Yagi, H., Whisstock, J.C., Norton, R.S.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4y1t|4y1t]]</td></tr>
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Description:
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y1s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4y1s RCSB], [http://www.ebi.ac.uk/pdbsum/4y1s PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Conroy, P.J]]
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== Function ==
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[[Category: Norton, R.S]]
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[[http://www.uniprot.org/uniprot/PERF_MOUSE PERF_MOUSE]] Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.<ref>PMID:3261391</ref> <ref>PMID:8164737</ref> <ref>PMID:7526382</ref> <ref>PMID:19446473</ref> <ref>PMID:21037563</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Conroy, P J]]
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[[Category: Norton, R S]]
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[[Category: Whisstock, J C]]
[[Category: Yagi, H]]
[[Category: Yagi, H]]
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[[Category: Whisstock, J.C]]
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[[Category: C2 domain]]
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[[Category: Calcium binding]]
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[[Category: Immune system]]
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[[Category: Perforin]]

Revision as of 12:30, 2 September 2015

Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes

4y1s, resolution 1.61Å

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