4ybh
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the human RAGE ectodomain (VC1C2 fragment) in complex with human S100A6== | |
| - | + | <StructureSection load='4ybh' size='340' side='right' caption='[[4ybh]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ybh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YBH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YBH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p2y|4p2y]]</td></tr> |
| - | [[Category: Andersen, G | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ybh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ybh OCA], [http://pdbe.org/4ybh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ybh RCSB], [http://www.ebi.ac.uk/pdbsum/4ybh PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RAGE_HUMAN RAGE_HUMAN]] Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.<ref>PMID:19906677</ref> [[http://www.uniprot.org/uniprot/S10A6_HUMAN S10A6_HUMAN]] May function as calcium sensor and contribute to cellular calcium signaling (Potential). May function by interacting with other proteins and indirectly play a role in the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Andersen, G R]] | ||
[[Category: Yatime, L]] | [[Category: Yatime, L]] | ||
| + | [[Category: Dimerization]] | ||
| + | [[Category: Ef-hand calcium binding protein]] | ||
| + | [[Category: Immunoglobulin domain]] | ||
| + | [[Category: Pattern recognition receptor]] | ||
| + | [[Category: Signaling complex]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 15:16, 2 March 2016
Crystal structure of the human RAGE ectodomain (VC1C2 fragment) in complex with human S100A6
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