5agq
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Solution structure of the TAM domain of human TIP5 BAZ2A involved in epigenetic regulation of rRNA genes== |
| - | + | <StructureSection load='5agq' size='340' side='right' caption='[[5agq]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5agq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AGQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5agq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5agq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5agq RCSB], [http://www.ebi.ac.uk/pdbsum/5agq PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN]] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Anosova, I]] | ||
| + | [[Category: Grummt, I]] | ||
[[Category: Kateb, F]] | [[Category: Kateb, F]] | ||
| - | [[Category: Tripsianes, K]] | ||
| - | [[Category: Sattler, M]] | ||
[[Category: Melnik, S]] | [[Category: Melnik, S]] | ||
| - | [[Category: | + | [[Category: Sattler, M]] |
| - | [[Category: | + | [[Category: Tripsianes, K]] |
| + | [[Category: Epigenetic]] | ||
| + | [[Category: Protein rna interaction]] | ||
| + | [[Category: Rrna gene silencing]] | ||
| + | [[Category: Tam domain]] | ||
| + | [[Category: Tip5/baz2a]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 13:06, 6 May 2015
Solution structure of the TAM domain of human TIP5 BAZ2A involved in epigenetic regulation of rRNA genes
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