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2mnt
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Solution structure of the PPIase domain of TbPar42== |
| + | <StructureSection load='2mnt' size='340' side='right' caption='[[2mnt]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2mnt]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MNT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MNT FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mnt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mnt RCSB], [http://www.ebi.ac.uk/pdbsum/2mnt PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Parvulins belong to a family of peptidyl-prolyl cis/trans isomerases (PPIases) that catalyze the cis/trans conformations of prolyl-peptidyl bonds. Herein, we characterized two novel parvulins, TbPIN1 and TbPAR42, in Trypanosoma brucei. TbPIN1, a 115 amino-acid protein, contains a single PPIase domain but lacks the N-terminal WW domain. Using NMR spectroscopy, TbPIN1 was found to exhibit PPIase activity toward a phosphorylated substrate. Overexpression of TbPIN1 can rescue the impaired temperature-sensitive phenotype in a mutant yeast strain. TbPAR42, containing 383 amino acids, comprises a novel FHA domain at its N terminus and a C-terminal PPIase domain but is a non-Pin1-type PPIase. Functionally, a knockdown of TbPAR42 in its procyclic form results in reduced proliferation rates suggesting an important role in cell growth. | ||
| - | + | Functional characterization of two novel parvulins in Trypanosoma brucei.,Goh JY, Lai CY, Tan LC, Yang D, He CY, Liou YC FEBS Lett. 2010 Jul 2;584(13):2901-8. doi: 10.1016/j.febslet.2010.04.077. Epub, 2010 May 11. PMID:20466001<ref>PMID:20466001</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Bayer, P]] | [[Category: Bayer, P]] | ||
[[Category: Rehic, E]] | [[Category: Rehic, E]] | ||
| + | [[Category: Isomerase]] | ||
| + | [[Category: Ppiase domain]] | ||
| + | [[Category: Tbpar42]] | ||
| + | [[Category: Tbpar45]] | ||
| + | [[Category: Trypanosoma]] | ||
Revision as of 12:49, 15 April 2015
Solution structure of the PPIase domain of TbPar42
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Categories: Bayer, P | Rehic, E | Isomerase | Ppiase domain | Tbpar42 | Tbpar45 | Trypanosoma
