4x97
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)== |
| - | + | <StructureSection load='4x97' size='340' side='right' caption='[[4x97]], [[Resolution|resolution]] 2.65Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4x97]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X97 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X97 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MAY:METHYL+ARACHIDONYL+FLUOROPHOSPHONATE'>MAY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x90|4x90]], [[4x91|4x91]], [[4x93|4x93]], [[4x94|4x94]], [[4x95|4x95]], [[4x96|4x96]], [[4x92|4x92]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x97 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x97 RCSB], [http://www.ebi.ac.uk/pdbsum/4x97 PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PAG15_HUMAN PAG15_HUMAN]] Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (By similarity). May have weak lysophospholipase activity. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Glukhova, A]] | [[Category: Glukhova, A]] | ||
| - | [[Category: Tesmer, J | + | [[Category: Tesmer, J J.G]] |
| + | [[Category: Acyltransferase]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Mafp]] | ||
| + | [[Category: Phospholipase]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 12:00, 11 March 2015
Crystal structure of Lysosomal Phospholipase A2 in complex with methyl arachidonyl fluorophosphonate (MAFP)
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