4y1l
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ''' | + | ==Ubc9 Homodimer The Missing Link in Poly-SUMO Chain Formation== |
| - | + | <StructureSection load='4y1l' size='340' side='right' caption='[[4y1l]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4y1l]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y1L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y1L FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y1l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4y1l RCSB], [http://www.ebi.ac.uk/pdbsum/4y1l PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/UBC9_HUMAN UBC9_HUMAN]] Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation.<ref>PMID:8668529</ref> <ref>PMID:11451954</ref> <ref>PMID:15809060</ref> <ref>PMID:19744555</ref> <ref>PMID:19638400</ref> <ref>PMID:17466333</ref> <ref>PMID:20077568</ref> [[http://www.uniprot.org/uniprot/RWDD3_HUMAN RWDD3_HUMAN]] Enhances the sumoylation of a number of proteins including HIF1A, PIAS and I-kappa-B, through direct interaction with UBC9. Has no effect on ubiquitination.<ref>PMID:17956732</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Aileen, Y A]] | ||
| + | [[Category: Ambaye, N D]] | ||
[[Category: Bzymek, K]] | [[Category: Bzymek, K]] | ||
[[Category: Chen, Y]] | [[Category: Chen, Y]] | ||
[[Category: Hu, W]] | [[Category: Hu, W]] | ||
| - | [[Category: Li, Y | + | [[Category: Li, Y J]] |
| - | + | ||
| - | + | ||
| - | + | ||
[[Category: Vega, R]] | [[Category: Vega, R]] | ||
| + | [[Category: Williams, J C]] | ||
| + | [[Category: Homodimer]] | ||
| + | [[Category: Ligase-nuclear protein complex]] | ||
| + | [[Category: Rwd]] | ||
| + | [[Category: Sumo]] | ||
| + | [[Category: Sumoylation]] | ||
| + | [[Category: Ubc9]] | ||
Revision as of 13:03, 6 May 2015
Ubc9 Homodimer The Missing Link in Poly-SUMO Chain Formation
| |||||||||||
Categories: Aileen, Y A | Ambaye, N D | Bzymek, K | Chen, Y | Hu, W | Li, Y J | Vega, R | Williams, J C | Homodimer | Ligase-nuclear protein complex | Rwd | Sumo | Sumoylation | Ubc9
