5ajp

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m (Protected "5ajp" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Crystal structure of the active form of GalNAc-T2 in complex with UDP and the glycopeptide MUC5AC-13==
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<StructureSection load='5ajp' size='340' side='right' caption='[[5ajp]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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The entry 5ajp is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ajp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJP FirstGlance]. <br>
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Authors: Lira-Navarrete, E., delasRivas, M., Companon, I., Pallares, M.C., Kong, Y., Iglesias-Fernandez, J., Bernardes, G.J.L., Peregrina, J.M., Rovira, C., Bernado, P., Bruscolini, P., Clausen, H., Lostao, A., Corzana, F., Hurtado-Guerrero, R.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ajn|5ajn]], [[5ajo|5ajo]]</td></tr>
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Description: Crystal structure of the active form of GalNAc-T2 in complex with UDP and the glycopeptide MUC5AC-13
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polypeptide_N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.41 2.4.1.41] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ajp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ajp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ajp RCSB], [http://www.ebi.ac.uk/pdbsum/5ajp PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/GALT2_HUMAN GALT2_HUMAN]] Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.<ref>PMID:9295285</ref> <ref>PMID:12438318</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Polypeptide N-acetylgalactosaminyltransferase]]
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[[Category: Bernado, P]]
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[[Category: Bernardes, G J.L]]
[[Category: Bruscolini, P]]
[[Category: Bruscolini, P]]
[[Category: Clausen, H]]
[[Category: Clausen, H]]
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[[Category: Kong, Y]]
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[[Category: Companon, I]]
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[[Category: Pallares, M.C]]
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[[Category: Corzana, F]]
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[[Category: Rovira, C]]
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[[Category: Peregrina, J.M]]
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[[Category: Iglesias-Fernandez, J]]
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[[Category: Bernardes, G.J.L]]
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[[Category: Hurtado-Guerrero, R]]
[[Category: Hurtado-Guerrero, R]]
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[[Category: Iglesias-Fernandez, J]]
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[[Category: Kong, Y]]
[[Category: Lira-Navarrete, E]]
[[Category: Lira-Navarrete, E]]
[[Category: Lostao, A]]
[[Category: Lostao, A]]
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[[Category: Delasrivas, M]]
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[[Category: Pallares, M C]]
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[[Category: Bernado, P]]
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[[Category: Peregrina, J M]]
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[[Category: Corzana, F]]
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[[Category: Rovira, C]]
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[[Category: Companon, I]]
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[[Category: DelasRivas, M]]
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[[Category: Active form]]
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[[Category: Afm]]
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[[Category: Coarse-grained model]]
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[[Category: Compact form]]
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[[Category: Extended form]]
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[[Category: Galnac-t2]]
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[[Category: Glycopeptide]]
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[[Category: Inactive form]]
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[[Category: Lectin domain]]
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[[Category: Sax]]
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[[Category: Transferase]]

Revision as of 12:02, 11 March 2015

Crystal structure of the active form of GalNAc-T2 in complex with UDP and the glycopeptide MUC5AC-13

5ajp, resolution 1.65Å

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