5ajq

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m (Protected "5ajq" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Human LOK (STK10) in complex with Bosutinib==
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<StructureSection load='5ajq' size='340' side='right' caption='[[5ajq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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The entry 5ajq is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ajq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJQ FirstGlance]. <br>
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Authors: Elkins, J.M., Salah, E., Krojer, T., Kopec, J., Bountra, C., Edwards, A.M., Knapp, S.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DB8:4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYLPIPERAZIN-1-YL)PROPOXY]QUINOLINE-3-CARBONITRILE'>DB8</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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Description: Human LOK (STK10) in complex with Bosutinib
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ajq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ajq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ajq RCSB], [http://www.ebi.ac.uk/pdbsum/5ajq PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Elkins, J.M]]
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== Disease ==
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[[Category: Knapp, S]]
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[[http://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:16175573</ref>
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[[Category: Krojer, T]]
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== Function ==
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[[http://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.<ref>PMID:11903060</ref> <ref>PMID:12639966</ref> <ref>PMID:19255442</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Bountra, C]]
[[Category: Bountra, C]]
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[[Category: Edwards, A M]]
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[[Category: Elkins, J M]]
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[[Category: Knapp, S]]
[[Category: Kopec, J]]
[[Category: Kopec, J]]
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[[Category: Edwards, A.M]]
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[[Category: Krojer, T]]
[[Category: Salah, E]]
[[Category: Salah, E]]
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[[Category: Transferase]]

Revision as of 12:03, 11 March 2015

Human LOK (STK10) in complex with Bosutinib

5ajq, resolution 2.20Å

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OCA

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