Sandbox Reserved 431
From Proteopedia
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<Structure load='4c9w' size='300' frame='true' align='right' caption='pdbcode, Insert caption here' scene='48/483888/Rainbow_cartoon_1/1' /> | <Structure load='4c9w' size='300' frame='true' align='right' caption='pdbcode, Insert caption here' scene='48/483888/Rainbow_cartoon_1/1' /> | ||
| - | <scene name='48/483888/Rainbow_cartoon_1/1'>Rainbow Cartoon</scene> | + | <scene name='48/483888/Rainbow_cartoon_1/1'>Rainbow Cartoon</scene> - This scene colors the protein from the N-terminus to the C terminus. |
| - | <scene name='48/483888/Space-filling_1/1'>Space-filling Model</scene> | + | <scene name='48/483888/Space-filling_1/1'>Space-filling Model</scene> - This scene colors nonpolar residues grey, polar residues red, and ligands bound to the protein green. |
| - | Close up of binding interaction | + | Close up of binding interaction - To be made. |
<br>Potential Questions:<br> | <br>Potential Questions:<br> | ||
Revision as of 23:30, 8 March 2015
| This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439. |
Contents |
Format Help
***We may want to consider changing our pdb code to 4c9x rather than 4c9w. The only difference between them is which enantiomer of crizotinib MTH1 is binding to. 4c9w = R and 4c9x = S. The S enantiomer is the one that causes inhibition. --Matt
OurMolecule
Introduction
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This is a sample scene created with SAT to by Group, and another to make of the protein.
Overall Structure
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Observe the beautiful alpha helicies.
You have a new view but you need to include the words to click on to get a green scene -- for your future green scenes! -Prof T
Binding Interactions
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Additional Features
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Quiz Question 1
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- This scene colors the protein from the N-terminus to the C terminus.
- This scene colors nonpolar residues grey, polar residues red, and ligands bound to the protein green.
Close up of binding interaction - To be made.
Potential Questions:
-Would this protein be expected to embed itself in the cell membrane? Why?
-TBD
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Quiz Question 2
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See Also
- MTH1 (7,8-dihydro-8-oxoguanine triphosphatase)
Credits
Introduction - Megi Marina
Overall Structure - Cassandra Martin
Drug Binding Site - Ben Ryter
Additional Features - Colin Hannahan
Quiz Question 1 - Matt Tuttle
Quiz Question 2 - Eric Rice
References
[http://www.nature.com/nature/journal/v508/n7495/pdf/nature13194.pdf Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy - Huber]
