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(→Binding Interactions) |
(→Binding Interactions) |
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==Binding Interactions== | ==Binding Interactions== | ||
| - | <Structure load='1a84' size='300' frame='true' align='right' caption='pdbcode, Insert caption here' scene | + | <Structure load='1a84' size='300' frame='true' align='right' caption='pdbcode, Insert caption here' scene='48/483886/4py1_binding_1/1' /> |
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LRRK2 contains binding sites for 6-[(2,5-dimethoxyphenyl)sulfanyl]-3-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazine which we will refer to by its PDB code, 2YK. | LRRK2 contains binding sites for 6-[(2,5-dimethoxyphenyl)sulfanyl]-3-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazine which we will refer to by its PDB code, 2YK. | ||
The residues involved in binging interactions are listed below: | The residues involved in binging interactions are listed below: | ||
| - | + | *LEU 903A | |
| - | + | *VAL 911A | |
| - | + | *GLY 1040A | |
| - | + | *GLU 979A | |
| - | + | *VAL 981A | |
These residues are highlighted in green and the ligand 2YK is shown in blue. | These residues are highlighted in green and the ligand 2YK is shown in blue. | ||
Revision as of 05:48, 11 March 2015
| This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439. |
Contents |
LRRK2/Kinase Inhibitors
Introduction
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This is our scene for depicting protein chains from the N terminus to C terminus using rainbow coloring.
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This scene focuses on the chemical component of 4PY1.
Overall Structure
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Binding Interactions
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LRRK2 contains binding sites for 6-[(2,5-dimethoxyphenyl)sulfanyl]-3-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazine which we will refer to by its PDB code, 2YK.
The residues involved in binging interactions are listed below:
- LEU 903A
- VAL 911A
- GLY 1040A
- GLU 979A
- VAL 981A
These residues are highlighted in green and the ligand 2YK is shown in blue.
Additional Features
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Quiz Question 1
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Quiz Question 2
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For our second question I am going to present a green scene with the binding pocket and the ligand shown. The green scene will show the details of the binding pocket including the secondary structures and the residues which make them up. I will then ask the student to think about the scene and give three alternations to the ligand which would make it a better competitive inhibitor.
See Also
- [2ZEJ]
- [Leucine-rich Repeat]
- [Crystal structure of a leucine-rich repeat protein]
- [Leucine-rich repeat-contain protein 4]
- [[1]]
Credits
Introduction - Megan Greiner
Overall Structure - Nick Barberio
Drug Binding Site - John Vetrano
Additional Features - Nicole Garvin
Quiz Question 1 - Charit Tippareddy
Quiz Question 2 - Peter Kelly
