2qqc
From Proteopedia
(Difference between revisions)
(New page: 200px {{Structure |PDB= 2qqc |SIZE=350|CAPTION= <scene name='initialview01'>2qqc</scene>, resolution 2.00Å |SITE= <scene name='pdbsite=AC1:Ag2+Binding+Site+...) |
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|PDB= 2qqc |SIZE=350|CAPTION= <scene name='initialview01'>2qqc</scene>, resolution 2.00Å | |PDB= 2qqc |SIZE=350|CAPTION= <scene name='initialview01'>2qqc</scene>, resolution 2.00Å | ||
|SITE= <scene name='pdbsite=AC1:Ag2+Binding+Site+For+Residue+A+671'>AC1</scene>, <scene name='pdbsite=AC2:Ag2+Binding+Site+For+Residue+E+671'>AC2</scene>, <scene name='pdbsite=AC3:Ag2+Binding+Site+For+Residue+A+672'>AC3</scene>, <scene name='pdbsite=AC4:Ag2+Binding+Site+For+Residue+K+671'>AC4</scene>, <scene name='pdbsite=AC5:Ag2+Binding+Site+For+Residue+I+671'>AC5</scene>, <scene name='pdbsite=AC6:Ag2+Binding+Site+For+Residue+I+672'>AC6</scene>, <scene name='pdbsite=AC7:Pyr+Binding+Site+For+Residue+B+53'>AC7</scene>, <scene name='pdbsite=AC8:Pyr+Binding+Site+For+Residue+D+53'>AC8</scene>, <scene name='pdbsite=AC9:Pyr+Binding+Site+For+Residue+F+53'>AC9</scene>, <scene name='pdbsite=BC1:Pyr+Binding+Site+For+Residue+H+53'>BC1</scene>, <scene name='pdbsite=BC2:Pyr+Binding+Site+For+Residue+J+53'>BC2</scene>, <scene name='pdbsite=BC3:Pyr+Binding+Site+For+Residue+L+53'>BC3</scene>, <scene name='pdbsite=BC4:Mpd+Binding+Site+For+Residue+C+700'>BC4</scene>, <scene name='pdbsite=BC5:Mpd+Binding+Site+For+Residue+E+700'>BC5</scene>, <scene name='pdbsite=BC6:Mpd+Binding+Site+For+Residue+B+700'>BC6</scene> and <scene name='pdbsite=BC7:Mpd+Binding+Site+For+Residue+I+700'>BC7</scene> | |SITE= <scene name='pdbsite=AC1:Ag2+Binding+Site+For+Residue+A+671'>AC1</scene>, <scene name='pdbsite=AC2:Ag2+Binding+Site+For+Residue+E+671'>AC2</scene>, <scene name='pdbsite=AC3:Ag2+Binding+Site+For+Residue+A+672'>AC3</scene>, <scene name='pdbsite=AC4:Ag2+Binding+Site+For+Residue+K+671'>AC4</scene>, <scene name='pdbsite=AC5:Ag2+Binding+Site+For+Residue+I+671'>AC5</scene>, <scene name='pdbsite=AC6:Ag2+Binding+Site+For+Residue+I+672'>AC6</scene>, <scene name='pdbsite=AC7:Pyr+Binding+Site+For+Residue+B+53'>AC7</scene>, <scene name='pdbsite=AC8:Pyr+Binding+Site+For+Residue+D+53'>AC8</scene>, <scene name='pdbsite=AC9:Pyr+Binding+Site+For+Residue+F+53'>AC9</scene>, <scene name='pdbsite=BC1:Pyr+Binding+Site+For+Residue+H+53'>BC1</scene>, <scene name='pdbsite=BC2:Pyr+Binding+Site+For+Residue+J+53'>BC2</scene>, <scene name='pdbsite=BC3:Pyr+Binding+Site+For+Residue+L+53'>BC3</scene>, <scene name='pdbsite=BC4:Mpd+Binding+Site+For+Residue+C+700'>BC4</scene>, <scene name='pdbsite=BC5:Mpd+Binding+Site+For+Residue+E+700'>BC5</scene>, <scene name='pdbsite=BC6:Mpd+Binding+Site+For+Residue+B+700'>BC6</scene> and <scene name='pdbsite=BC7:Mpd+Binding+Site+For+Residue+I+700'>BC7</scene> | ||
| - | |LIGAND= <scene name='pdbligand=AG2:AGMATINE'>AG2</scene>, | + | |LIGAND= <scene name='pdbligand=AG2:AGMATINE'>AG2</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Arginine_decarboxylase Arginine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.19 4.1.1.19] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginine_decarboxylase Arginine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.19 4.1.1.19] </span> |
|GENE= pdaD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii]) | |GENE= pdaD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii]) | ||
| + | |DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1945 COG1945], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK01285 PRK01285]</span> | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qqc OCA], [http://www.ebi.ac.uk/pdbsum/2qqc PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=2qqc RCSB]</span> | ||
}} | }} | ||
'''E109Q mutant of Pyruvoyl-dependent Arginine Decarboxylase from Methanococcus jannashii''' | '''E109Q mutant of Pyruvoyl-dependent Arginine Decarboxylase from Methanococcus jannashii''' | ||
| - | |||
| - | ==Overview== | ||
| - | Human deoxycytidine kinase (dCK) is involved in the nucleotide-biosynthesis salvage pathway and has also been shown to phosphorylate several antitumor and antiviral prodrugs. The structures of dCK alone and the dead-end complex of dCK with substrate nucleoside and product ADP or UDP have previously been reported; however, there is currently no structure available for a substrate or product complex. Here, the structures of dCK complexes with the products dCMP, UDP and Mg2+ ion, and with dAMP, UDP and Mg2+ ion are reported. Structural comparisons show that the product complexes with UDP and a dead-end complex with substrate and UDP have similar active-site conformations. | ||
==About this Structure== | ==About this Structure== | ||
2QQC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QQC OCA]. | 2QQC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QQC OCA]. | ||
| - | |||
| - | ==Reference== | ||
| - | Structures of human deoxycytidine kinase product complexes., Soriano EV, Clark VC, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2007 Dec;63(Pt 12):1201-7. Epub 2007, Nov 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18084067 18084067] | ||
[[Category: Arginine decarboxylase]] | [[Category: Arginine decarboxylase]] | ||
[[Category: Methanocaldococcus jannaschii]] | [[Category: Methanocaldococcus jannaschii]] | ||
| Line 25: | Line 21: | ||
[[Category: Ealick, S E.]] | [[Category: Ealick, S E.]] | ||
[[Category: Soriano, E S.]] | [[Category: Soriano, E S.]] | ||
| - | [[Category: AG2]] | ||
| - | [[Category: MPD]] | ||
| - | [[Category: PYR]] | ||
[[Category: arginine decarboxylase]] | [[Category: arginine decarboxylase]] | ||
[[Category: autoprocessing]] | [[Category: autoprocessing]] | ||
| Line 36: | Line 29: | ||
[[Category: serinolysis]] | [[Category: serinolysis]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 10:02:37 2008'' |
Revision as of 08:02, 26 March 2008
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| , resolution 2.00Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | , , , , , , , , , , , , , , and | ||||||
| Ligands: | , , | ||||||
| Gene: | pdaD (Methanocaldococcus jannaschii) | ||||||
| Activity: | Arginine decarboxylase, with EC number 4.1.1.19 | ||||||
| Domains: | COG1945, PRK01285 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, JenaLib, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
E109Q mutant of Pyruvoyl-dependent Arginine Decarboxylase from Methanococcus jannashii
About this Structure
2QQC is a Protein complex structure of sequences from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.
Page seeded by OCA on Wed Mar 26 10:02:37 2008
