Catechol O-methyltransferase
From Proteopedia
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| - | <StructureSection load='3a7e' size=' | + | <StructureSection load='3a7e' size='450' side='right' caption='Structure of human catechol O-methyltransferase complex with SAM and dinitrocatechol (PDB entry [[3a7e]])' scene='55/551215/Cv/1'> |
'''Catechol O-methyltransferase''' (COMT) methylates catecholamines like dopamine, epinephrine and norepinephrine. The cofactor S-adenosyl-L-methionine (SAM) serves as the methyl donor in the reaction and is converted to to S-adenosyl-L-homocysteine (SAH) by the reaction. The Parkinson Disease drug levodopa is a substrate of COMT and COMT inhibitors like entacapone are used with levodopa in the disease treatment. | '''Catechol O-methyltransferase''' (COMT) methylates catecholamines like dopamine, epinephrine and norepinephrine. The cofactor S-adenosyl-L-methionine (SAM) serves as the methyl donor in the reaction and is converted to to S-adenosyl-L-homocysteine (SAH) by the reaction. The Parkinson Disease drug levodopa is a substrate of COMT and COMT inhibitors like entacapone are used with levodopa in the disease treatment. | ||
Revision as of 09:16, 23 November 2015
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