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Introduction

This is a sample scene created with SAT to by Group, and another to make of the protein.

Overall Structure

-Glycogen Synthase Kinase-3 (GSK-3) is a serine/threonine protein kinase -2 isoforms: alpha and beta, that are 97% homologous in their catalytic domain, but diverse at the N and C terminus. -Both isoforms have a conserved N-terminal serine reside (S21 for alpha and S9 for beta) -Phosphorylation of the N-terminal serine residue plays an important role for further activity -Classified the PDB structures into three groups a

Mishra, Nibha et al. Structure based virtual screening of GSK-3beta: Importance of protein flexibility and induced fit, 2009. Bioorganic & Medicinal Chemistry Letters, 2009, Vol. 19 Iss. 19, pp. 5582-5585. Retreived from http://www.sciencedirect.com/science/article/pii/S0960894X09011780

Binding Interactions

Additional Features

Quiz Question 1

Which isoform of GSK-3 would work best for ___ function in ___ pathway?

Quiz Question 2

How might the location of the active sites enhance each isoform's versatility as a serine threonine protein kinase?

J.A. Bertrand, S. Thieffine, A. Vulpetti, C. Cristiani, B. Valsasina, S. Knapp, H.M. Kalisz, M. Flocco, Structural Characterization of the GSK-3β Active Site Using Selective and Non-selective ATP-mimetic Inhibitors, Journal of Molecular Biology, Volume 333, Issue 2, 17 October 2003, Pages 393-407, ISSN 0022-2836, http://dx.doi.org/10.1016/j.jmb.2003.08.031.

(http://www.sciencedirect.com/science/article/pii/S0022283603010593) Keywords: glycogen synthase kinase-3; selective inhibitors; signal transduction; structure-based design; X-ray crystallography

See Also

• UvrABC
• Glycogen Synthase Kinase 3
• Serine/Threonie Protein Kinase
• Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Inhibitor 7d
• Glycogen Synthase Kinase 3 Beta complexed with AMP-PNP
• Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Leucettine L4
• Glycogen Synthase Kinase 3 beta (GSK3B) complexed with a ruthenium octasporine ligand (OS1)

Credits

Introduction - name of team member

Overall Structure - name of team member

Drug Binding Site - name of team member

Additional Features - name of team member

Quiz Question 1 - Nerses Haroutunian

Quiz Question 2 - Nick Hoffman-klaucke

References