Sandbox Reserved 433
From Proteopedia
(Difference between revisions)
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<scene name='48/483890/1q3d/1'>1q3d structure</scene> | <scene name='48/483890/1q3d/1'>1q3d structure</scene> | ||
==Binding Interactions== | ==Binding Interactions== | ||
| + | 1)Folding of protein | ||
| + | a) location and description of position of alpha and beta sheets (Show in separate color on green screen) | ||
| + | b) | ||
| + | 2)Substrate binding | ||
| + | a) “phosphate-binding” pocket: describe three crucial basic residues (Show in different color on green screen) | ||
| + | b) GSK-3 substrates and binding specifics- S/TxxxS/T (S=Serine, T=threonine, X= any amino acid) | ||
| + | |||
| + | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217193/ | ||
| + | http://www.rcsb.org/pdb/explore/explore.do?pdbId=1Q3D | ||
==Additional Features== | ==Additional Features== | ||
| Line 32: | Line 41: | ||
==Quiz Question 2== | ==Quiz Question 2== | ||
| - | How might the location of the active sites enhance each isoform's versatility as a serine threonine protein kinase? | ||
| - | |||
| - | <scene name='48/483890/Staurosporine_in_active_sites/1'>TextToBeDisplayed</scene> | ||
| - | J.A. Bertrand, S. Thieffine, A. Vulpetti, C. Cristiani, B. Valsasina, S. Knapp, H.M. Kalisz, M. Flocco, Structural Characterization of the GSK-3β Active Site Using Selective and Non-selective ATP-mimetic Inhibitors, Journal of Molecular Biology, Volume 333, Issue 2, 17 October 2003, Pages 393-407, ISSN 0022-2836, http://dx.doi.org/10.1016/j.jmb.2003.08.031. | ||
| - | (http://www.sciencedirect.com/science/article/pii/S0022283603010593) | ||
| - | Keywords: glycogen synthase kinase-3; selective inhibitors; signal transduction; structure-based design; X-ray crystallography | ||
==See Also== | ==See Also== | ||
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Quiz Question 1 - Nerses Haroutunian | Quiz Question 1 - Nerses Haroutunian | ||
| - | Quiz Question 2 - | + | Quiz Question 2 - name of team member |
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 21:52, 12 March 2015
| This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439. |
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