Cocaine esterase
From Proteopedia
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| - | {{STRUCTURE_1l7q| PDB=1l7q | SIZE= | + | {{STRUCTURE_1l7q| PDB=1l7q | SIZE=350| SCENE= |right|CAPTION=Cocaine esterase complex with reaction product benzoic acid, [[1l7q]]}} |
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Revision as of 11:55, 8 December 2015
Cocaine esterase (CocE) catalyzes the hydrolysis of the benzoyl ester of cocaine to ecgonine methyl ester and benzoic acid. CocE contains 3 domains. Domain 1 contains the catalytic triad: Ser, Asp and His typical of the hydrolase family. Domains 2 and 3 are involved in substrate recognition. CocE is produced by bacteria which thrive in soil of cocaine-producing plants. These bacteria use cocaine as their sole source of carbon and nitrogen. CocE is being investigated as a possible therapeutic agent for treatment of cocaine abuse.
3D structures of cocaine esterase
Updated on 08-December-2015
