2n08

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'''Unreleased structure'''
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==NMR structure of a short hydrophobic 11mer peptide in 25 mM SDS solution==
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<StructureSection load='2n08' size='340' side='right' caption='[[2n08]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2n08]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N08 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2n09|2n09]], [[2n0i|2n0i]], [[2n0n|2n0n]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2n08 RCSB], [http://www.ebi.ac.uk/pdbsum/2n08 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cyclic constraints are incorporated here into an 11-residue analogue of the N-terminus of glucagon-like peptide-1 (GLP-1) to investigate effects of structure on agonist activity. Cyclization through linking side chains of residues 2 and 5 or 5 and 9 produced agonists at nM concentrations in a cAMP assay. 2D-NMR and CD spectra revealed an N-terminal beta-turn and a C-terminal helix that differentially influenced affinity and agonist potency. These structures can inform development of small molecule agonists of the GLP-1 receptor to treat type 2 diabetes.
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The entry 2n08 is ON HOLD
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Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonists.,Hoang HN, Song K, Hill TA, Derksen DR, Edmonds DJ, Kok WM, Limberakis C, Liras S, Loria PM, Mascitti V, Mathiowetz AM, Mitchell JM, Piotrowski DW, Price DA, Stanton RV, Suen JY, Withka JM, Griffith DA, Fairlie DP J Med Chem. 2015 Apr 3. PMID:25839426<ref>PMID:25839426</ref>
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Authors: Hoang, H.N., Song, K., Hill, T.A., Derksen, D.R., Edmonds, D.J., Kok, W.M., Limberakis, C., Liras, S., Loria, P.M., Mascitti, V., Mathiowetz, A.M., Mitchell, J.M., Piotrowski, D.W., Price, D.A., Stanton, R.V., Suen, J.Y., Withka, J.M., Griffith, D.A., Fairlie, D.P.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description: NMR structure of a short hydrophobic 11mer peptide in 25 mM SDS solution
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Withka, J.M]]
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__TOC__
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[[Category: Suen, J.Y]]
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</StructureSection>
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[[Category: Edmonds, D.J]]
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[[Category: Derksen, D R]]
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[[Category: Kok, W.M]]
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[[Category: Edmonds, D J]]
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[[Category: Loria, P.M]]
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[[Category: Fairlie, D P]]
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[[Category: Griffith, D A]]
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[[Category: Hill, T A]]
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[[Category: Hoang, H N]]
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[[Category: Kok, W M]]
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[[Category: Limberakis, C]]
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[[Category: Liras, S]]
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[[Category: Loria, P M]]
[[Category: Mascitti, V]]
[[Category: Mascitti, V]]
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[[Category: Fairlie, D.P]]
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[[Category: Mathiowetz, A M]]
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[[Category: Liras, S]]
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[[Category: Mitchell, J M]]
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[[Category: Hill, T.A]]
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[[Category: Piotrowski, D W]]
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[[Category: Limberakis, C]]
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[[Category: Price, D A]]
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[[Category: Mitchell, J.M]]
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[[Category: Hoang, H.N]]
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[[Category: Piotrowski, D.W]]
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[[Category: Price, D.A]]
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[[Category: Song, K]]
[[Category: Song, K]]
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[[Category: Mathiowetz, A.M]]
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[[Category: Stanton, R V]]
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[[Category: Griffith, D.A]]
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[[Category: Suen, J Y]]
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[[Category: Stanton, R.V]]
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[[Category: Withka, J M]]
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[[Category: Derksen, D.R]]
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[[Category: De novo protein]]
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[[Category: Glp-1r agonist]]
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[[Category: Hydrophobic peptide]]

Revision as of 12:44, 15 April 2015

NMR structure of a short hydrophobic 11mer peptide in 25 mM SDS solution

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