Cyclic GMP-AMP synthase
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | '''Cyclic GMP-AMP synthase''' (CGAS) binds to DNA and catalyzes cGAMP synthesis. The cGAMP activates the type-I interferon pathway. | + | '''Cyclic GMP-AMP synthase''' (CGAS) binds to DNA and catalyzes cGAMP synthesis. The cGAMP activates the type-I interferon pathway. <ref>PMID:23258413</ref> |
== Disease == | == Disease == | ||
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Mice lacking CGAS are more vulnerable to lethal infection by DNA virus. | Mice lacking CGAS are more vulnerable to lethal infection by DNA virus. | ||
| - | == Relevance == | ||
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| - | == Structural highlights == | ||
</StructureSection> | </StructureSection> | ||
Revision as of 08:53, 16 December 2015
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3D structures of cyclic GMP-AMP synthase
Updated on 16-December-2015
References
- ↑ Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012, Dec 20. PMID:23258413 doi:10.1126/science.1232458
