4q23
From Proteopedia
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==The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates== | ==The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates== | ||
<StructureSection load='4q23' size='340' side='right' caption='[[4q23]], [[Resolution|resolution]] 1.98Å' scene=''> | <StructureSection load='4q23' size='340' side='right' caption='[[4q23]], [[Resolution|resolution]] 1.98Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kfa|4kfa]], [[4kpd|4kpd]], [[4kpj|4kpj]], [[4kqs|4kqs]], [[4kqu|4kqu]], [[4kq5|4kq5]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kfa|4kfa]], [[4kpd|4kpd]], [[4kpj|4kpj]], [[4kqs|4kqs]], [[4kqu|4kqu]], [[4kq5|4kq5]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q23 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q23 RCSB], [http://www.ebi.ac.uk/pdbsum/4q23 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q23 OCA], [http://pdbe.org/4q23 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q23 RCSB], [http://www.ebi.ac.uk/pdbsum/4q23 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q23 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | [[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | ||
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| + | ==See Also== | ||
| + | *[[Farnesyl diphosphate synthase|Farnesyl diphosphate synthase]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 17:00, 4 January 2017
The role of threonine 201 and tyrosine 204 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
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Categories: Barnett, B L | Delft, F Von | Dunford, J E | Ebetino, F H | Evdokimov, A | Kavanagh, K L | Kwaasi, A A | Muniz, J R.C | Oppermann, U | Pilka, E S | Russell, R G.G | Tsoumpra, M K | Walter, R L | Alpha helical prenyltransferase | Bisphosphonate | Cholesterol synthesis | Dimethylallyl pyrophospahte | Isopentyl pyrophosphate | Isoprene biosynthesis | Isoprenoid pathway | Lipid synthesis | Steroid biosynthesis | Transferase
