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Deaminase
From Proteopedia
(Difference between revisions)
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<StructureSection load='1aln' size='350' side='right' caption='Structure of cytidine deaminase complex with deazacytosine (PDB entry [[1aln]])' scene=''> | <StructureSection load='1aln' size='350' side='right' caption='Structure of cytidine deaminase complex with deazacytosine (PDB entry [[1aln]])' scene=''> | ||
| + | == Function == | ||
| - | '''Deaminase''' removes an amine group from | + | '''Deaminase''' removes an amine group from an amino acid and the rest of the molecule is recycled. <br /> |
* '''Cytosine deaminase''' (CDA) converts cytosine to uracil. <br /> | * '''Cytosine deaminase''' (CDA) converts cytosine to uracil. <br /> | ||
| - | * '''Cytidine deaminase''' (CDDA) converts cytidine to uridine. | + | * '''Cytidine deaminase''' (CDDA) converts cytidine to uridine. <ref>PMID:12651994</ref> <br /> |
* '''5-methylcytosine deaminase''' (MCDA) produces thymine. <br /> | * '''5-methylcytosine deaminase''' (MCDA) produces thymine. <br /> | ||
| - | * '''Guanine deaminase''' (GDA) converts guanine to xanthine. <br /> | + | * '''Guanine deaminase''' (GDA) converts guanine to xanthine. <ref>PMID:22662200</ref><br /> |
* '''Adenine deaminase''' (ADA) converts adenine to hypoxanthine.<br /> | * '''Adenine deaminase''' (ADA) converts adenine to hypoxanthine.<br /> | ||
* '''Glucosamine 6-phosphate deaminase''' (GPD) converts glucosamine 6-phosphate to fructose 6-phosphate.<br /> | * '''Glucosamine 6-phosphate deaminase''' (GPD) converts glucosamine 6-phosphate to fructose 6-phosphate.<br /> | ||
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* '''L-serine deaminase''' (LSD) converts L-serine to pyruvate.<br /> | * '''L-serine deaminase''' (LSD) converts L-serine to pyruvate.<br /> | ||
* '''D-serine deaminase''' (DSD) converts D-serine to pyruvate.<br /> | * '''D-serine deaminase''' (DSD) converts D-serine to pyruvate.<br /> | ||
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| + | == Relevance == | ||
| + | |||
| + | Cytosine deaminase is used in cancer therapy. After treatment by 5-fluorouracil, the cytosine deaminase gene is introduced to the tumor resulting in intratumor chemotherapy. <ref>PMID:17938268</ref> | ||
</StructureSection> | </StructureSection> | ||
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**[[3gwq]] – DSD - ''Burkholderia xenovorans''<BR /> | **[[3gwq]] – DSD - ''Burkholderia xenovorans''<BR /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 12:19, 21 December 2015
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3D Structures of deaminase
Updated on 21-December-2015
References
- ↑ Ciccone DS, Natelson BH. Comorbid illness in women with chronic fatigue syndrome: a test of the single syndrome hypothesis. Psychosom Med. 2003 Mar-Apr;65(2):268-75. PMID:12651994
- ↑ Egeblad L, Welin M, Flodin S, Graslund S, Wang L, Balzarini J, Eriksson S, Nordlund P. Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism. PLoS One. 2012;7(5):e37724. Epub 2012 May 25. PMID:22662200 doi:10.1371/journal.pone.0037724
- ↑ Negroni L, Samson M, Guigonis JM, Rossi B, Pierrefite-Carle V, Baudoin C. Treatment of colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90beta phosphorylation. Mol Cancer Ther. 2007 Oct;6(10):2747-56. PMID:17938268 doi:http://dx.doi.org/10.1158/1535-7163.MCT-07-0040
