Deoxyuridine 5'-triphosphate nucleotidohydrolase
From Proteopedia
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| + | <StructureSection load='1smc' size='350' side='right' caption='dUTPase trimer complex with dUTP (stick model), nitrate and Tris (PDB entry [[1smc]])' scene=''> | ||
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| - | '''Deoxyuridine 5’-triphosphate nucleotidohydrolase''' (DUTP) catalyzes the conversion of dUTP to dUMP and pyrophosphate (PPi). DUTP plays a key role in keeping significant amounts of dUTP from the DNA synthesis pathway. | + | == Function == |
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| + | '''Deoxyuridine 5’-triphosphate nucleotidohydrolase''' (DUTP) catalyzes the conversion of dUTP to dUMP and pyrophosphate (PPi). DUTP plays a key role in keeping significant amounts of dUTP from the DNA synthesis pathway. | ||
| + | Prokaryotic DUTP contains metal ion. <ref>PMID:11742345</ref> | ||
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| + | == Relevance == | ||
| + | DUTP inhibitors are being tested as possible anti-bacterial agents targeting diseases like malaria, leishmaniasis, tuberculosis and trypanosomiasis. | ||
| + | </StructureSection> | ||
==3D structures of dUTPase== | ==3D structures of dUTPase== | ||
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**[[4aoo]], [[4apz]], [[4aoz]] - BsDUTP + Mg + PPi + uridine<br /> | **[[4aoo]], [[4apz]], [[4aoz]] - BsDUTP + Mg + PPi + uridine<br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:11, 23 December 2015
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3D structures of dUTPase
Updated on 23-December-2015
References
- ↑ Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA. Crystal structure of a bacterial cocaine esterase. Nat Struct Biol. 2002 Jan;9(1):17-21. PMID:11742345 doi:10.1038/nsb742
