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4v5z

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Revision as of 08:08, 31 August 2015

Structure of a mammalian 80S ribosome obtained by docking homology models of the RNA and proteins into an 8.7 A cryo-EM map

Structural highlights

4v5z is a 86 chain structure with sequence from Canis lupus familiaris. This structure supersedes and combines the now removed PDB entries 2zkq and 2zkr. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	2zkq, 2zkr
Resources:	FirstGlance, OCA, RCSB, PDBsum

Warning: this is a large structure, and loading might take a long time or not happen at all.

Publication Abstract from PubMed

In this paper, we present a structure of the mammalian ribosome determined at approximately 8.7 A resolution by electron cryomicroscopy and single-particle methods. A model of the ribosome was created by docking homology models of subunit rRNAs and conserved proteins into the density map. We then modeled expansion segments in the subunit rRNAs and found unclaimed density for approximately 20 proteins. In general, many conserved proteins and novel proteins interact with expansion segments to form an integrated framework that may stabilize the mature ribosome. Our structure provides a snapshot of the mammalian ribosome at the beginning of translation and lends support to current models in which large movements of the small subunit and L1 stalk occur during tRNA translocation. Finally, details are presented for intersubunit bridges that are specific to the eukaryotic ribosome. We suggest that these bridges may help reset the conformation of the ribosome to prepare for the next cycle of chain elongation.

Structure of the mammalian 80S ribosome at 8.7 A resolution.,Chandramouli P, Topf M, Menetret JF, Eswar N, Cannone JJ, Gutell RR, Sali A, Akey CW Structure. 2008 Apr;16(4):535-48. PMID:18400176^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Chandramouli P, Topf M, Menetret JF, Eswar N, Cannone JJ, Gutell RR, Sali A, Akey CW. Structure of the mammalian 80S ribosome at 8.7 A resolution. Structure. 2008 Apr;16(4):535-48. PMID:18400176 doi:10.1016/j.str.2008.01.007

1 Structural highlights
2 Publication Abstract from PubMed
3 References

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OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4v5z"

@@ Line 2: / Line 2: @@
 <StructureSection load='4v5z' size='340' side='right' caption='[[4v5z]], [[Resolution|resolution]] 8.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4v5z]] is a 86 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. This structure supersedes the now removed PDB entries  and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2zkr 2zkr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V5Z FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4v5z]] is a 86 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. This structure supersedes and combines the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2zkq 2zkq] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2zkr 2zkr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V5Z FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zkq|2zkq]], [[2zkr|2zkr]]</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v5z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v5z RCSB], [http://www.ebi.ac.uk/pdbsum/4v5z PDBsum]</span></td></tr>
 </table>
+{{Large structure}}
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==

4v5z

From Proteopedia

Revision as of 08:08, 31 August 2015

Structure of a mammalian 80S ribosome obtained by docking homology models of the RNA and proteins into an 8.7 A cryo-EM map

Structural highlights

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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