3x43

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m (Protected "3x43" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Crystal structure of O-ureido-L-serine synthase==
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<StructureSection load='3x43' size='340' side='right' caption='[[3x43]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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The entry 3x43 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3x43]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X43 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X43 FirstGlance]. <br>
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Authors: Matoba, Y., Uda, N., Oda, K., Sugiyama, M.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x43 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3x43 RCSB], [http://www.ebi.ac.uk/pdbsum/3x43 PDBsum]</span></td></tr>
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Description: Crystal structure of O-ureido-L-serine synthase
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Oda, K]]
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[[http://www.uniprot.org/uniprot/DCSD_STRLA DCSD_STRLA]] Involved in the biosynthesis of the antibiotic D-cycloserine (DCS), a cyclic structural analog of D-alanine, used as an antitubercular agent. Catalyzes the addition of hydroxyurea on O-acetyl-L-serine (OAS) to yield O-ureido-L-serine. It prefers sulfide as the second substrate, followed by hydroxyurea, L-homocysteine, and thiosulfate.<ref>PMID:20086163</ref> <ref>PMID:23529730</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Matoba, Y]]
[[Category: Matoba, Y]]
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[[Category: Uda, N]]
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[[Category: Oda, K]]
[[Category: Sugiyama, M]]
[[Category: Sugiyama, M]]
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[[Category: Uda, N]]
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[[Category: D-cycloserine]]
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[[Category: Synthase]]
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[[Category: Transferase]]
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[[Category: Type ii plp enzyme]]

Revision as of 14:45, 29 July 2015

Crystal structure of O-ureido-L-serine synthase

3x43, resolution 2.25Å

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