4yk8

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'''Unreleased structure'''
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==Crystal structure of the Atg101-Atg13 complex from fission yeast==
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<StructureSection load='4yk8' size='340' side='right' caption='[[4yk8]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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The entry 4yk8 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4yk8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YK8 FirstGlance]. <br>
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Authors: Suzuki, H., Noda, N.N.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yk8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yk8 RCSB], [http://www.ebi.ac.uk/pdbsum/4yk8 PDBsum]</span></td></tr>
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</table>
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Description:
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== Function ==
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[[Category: Unreleased Structures]]
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[[http://www.uniprot.org/uniprot/MUG66_SCHPO MUG66_SCHPO]] Autophagy factor required for autophagosome formation (By similarity). Has a role in meiosis and sporulation.<ref>PMID:16303567</ref> [[http://www.uniprot.org/uniprot/ATG13_SCHPO ATG13_SCHPO]] Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Autophagy functions to supply nitrogen and is activated when cells cannot access exogenous nitrogen, thus ensuring that they can adapt and subsequently propagate. Finally, atg13 is also required for glycogen storage during stationary phase and has a role in meiosis and sporulation.<ref>PMID:16303567</ref> <ref>PMID:17295836</ref> <ref>PMID:19778961</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Noda, N N]]
[[Category: Suzuki, H]]
[[Category: Suzuki, H]]
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[[Category: Noda, N.N]]
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[[Category: Autophagy]]
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[[Category: Horma]]
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[[Category: Protein transport]]

Revision as of 12:47, 3 June 2015

Crystal structure of the Atg101-Atg13 complex from fission yeast

4yk8, resolution 3.00Å

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