2r9r
From Proteopedia
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|PDB= 2r9r |SIZE=350|CAPTION= <scene name='initialview01'>2r9r</scene>, resolution 2.40Å | |PDB= 2r9r |SIZE=350|CAPTION= <scene name='initialview01'>2r9r</scene>, resolution 2.40Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene> | + | |LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= Kcnab2, Ckbeta2, Kcnb3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), kcna2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | |GENE= Kcnab2, Ckbeta2, Kcnb3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), kcna2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2a79|2a79]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9r OCA], [http://www.ebi.ac.uk/pdbsum/2r9r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2r9r RCSB]</span> | ||
}} | }} | ||
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[[Category: Mackinnon, R.]] | [[Category: Mackinnon, R.]] | ||
[[Category: Tao, X.]] | [[Category: Tao, X.]] | ||
| - | [[Category: K]] | ||
| - | [[Category: NAP]] | ||
| - | [[Category: PGW]] | ||
[[Category: cytoplasm]] | [[Category: cytoplasm]] | ||
[[Category: eukaryotic]] | [[Category: eukaryotic]] | ||
| Line 50: | Line 50: | ||
[[Category: voltage-gated channel]] | [[Category: voltage-gated channel]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:58:06 2008'' |
Revision as of 01:58, 31 March 2008
| |||||||
| , resolution 2.40Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Gene: | Kcnab2, Ckbeta2, Kcnb3 (Rattus norvegicus), kcna2 (Rattus norvegicus) | ||||||
| Related: | 2a79
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Shaker family voltage dependent potassium channel (kv1.2-kv2.1 paddle chimera channel) in association with beta subunit
Overview
Voltage-dependent K+ (Kv) channels repolarize the action potential in neurons and muscle. This type of channel is gated directly by membrane voltage through protein domains known as voltage sensors, which are molecular voltmeters that read the membrane voltage and regulate the pore. Here we describe the structure of a chimaeric voltage-dependent K+ channel, which we call the 'paddle-chimaera channel', in which the voltage-sensor paddle has been transferred from Kv2.1 to Kv1.2. Crystallized in complex with lipids, the complete structure at 2.4 angstrom resolution reveals the pore and voltage sensors embedded in a membrane-like arrangement of lipid molecules. The detailed structure, which can be compared directly to a large body of functional data, explains charge stabilization within the membrane and suggests a mechanism for voltage-sensor movements and pore gating.
About this Structure
2R9R is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment., Long SB, Tao X, Campbell EB, MacKinnon R, Nature. 2007 Nov 15;450(7168):376-82. PMID:18004376
Page seeded by OCA on Mon Mar 31 04:58:06 2008
Categories: Protein complex | Rattus norvegicus | Campbell, E B. | Long, S B. | Mackinnon, R. | Tao, X. | Cytoplasm | Eukaryotic | Ion channel | Ion transport | Ionic channel | Kv1 2 | Kv2 1 | Membrane protein | Nadp | Paddle chimera channel | Phosphorylation | Potassium channel | Potassium transport | Protein transport | Shaker | Transport | Transport protein | Voltage dependent | Voltage sensor | Voltage-gated channel
