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2rak

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|PDB= 2rak |SIZE=350|CAPTION= <scene name='initialview01'>2rak</scene>, resolution 3.00&Aring;
|PDB= 2rak |SIZE=350|CAPTION= <scene name='initialview01'>2rak</scene>, resolution 3.00&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=PIB:2-(BUTANOYLOXY)-1-{[(HYDROXY{[2,3,4,6-TETRAHYDROXY-5-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL)OXY]METHYL}ETHYL BUTANOATE'>PIB</scene>
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|LIGAND= <scene name='pdbligand=PIB:2-(BUTANOYLOXY)-1-{[(HYDROXY{[2,3,4,6-TETRAHYDROXY-5-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL)OXY]METHYL}ETHYL+BUTANOATE'>PIB</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= SNX9, SH3PX1, SH3PXD3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= SNX9, SH3PX1, SH3PXD3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
 +
|DOMAIN=
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|RELATEDENTRY=[[2rai|2RAI]], [[2raj|2RAJ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rak OCA], [http://www.ebi.ac.uk/pdbsum/2rak PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rak RCSB]</span>
}}
}}
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[[Category: Rak, A.]]
[[Category: Rak, A.]]
[[Category: Rasmuson, E.]]
[[Category: Rasmuson, E.]]
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[[Category: PIB]]
 
[[Category: bar domain]]
[[Category: bar domain]]
[[Category: membrane transport]]
[[Category: membrane transport]]
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[[Category: tubulation]]
[[Category: tubulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:34:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:58:15 2008''

Revision as of 01:58, 31 March 2008

Image:2rak.jpg


PDB ID 2rak

Drag the structure with the mouse to rotate
, resolution 3.00Å
Ligands:
Gene: SNX9, SH3PX1, SH3PXD3A (Homo sapiens)
Related: 2RAI, 2RAJ


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



PI(3)P bound PX-BAR membrane remodeling unit of Sorting Nexin 9


Overview

Sorting nexins (SNXs) form a family of proteins known to interact with components in the endosomal system and to regulate various steps of vesicle transport. Sorting nexin 9 (SNX9) is involved in the late stages of clathrin-mediated endocytosis in non-neuronal cells, where together with the GTPase dynamin, it participates in the formation and scission of the vesicle neck. We report here crystal structures of the functional membrane-remodeling unit of SNX9 and show that it efficiently tubulates lipid membranes in vivo and in vitro. Elucidation of the protein superdomain structure, together with mutational analysis and biochemical and cell biological experiments, demonstrated how the SNX9 PX and BAR domains work in concert in targeting and tubulation of phosphoinositide-containing membranes. The study provides insights into the SNX9-induced membrane modulation mechanism.

About this Structure

2RAK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The PX-BAR membrane-remodeling unit of sorting nexin 9., Pylypenko O, Lundmark R, Rasmuson E, Carlsson SR, Rak A, EMBO J. 2007 Nov 14;26(22):4788-800. Epub 2007 Oct 18. PMID:17948057

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