We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
Ectonucleoside triphosphate diphosphohydrolase
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Function == | == Function == | ||
| - | '''Ectonucleoside triphosphate diphosphohydrolase (NTPDase)''' hydrolyzes nucleoside 5’-triphosphate to nucleoside 5’-phosphate and 2 phosphates. NTPDase can hydrolyze ATP and ADP. NTPDase has an important role in regulating neutrophil chemotaxis. NTPDase 1,2,3,8 are cell surface enzymes with catalytic sites facing extracellularly while other NTPDases act intracellularly. NTPDase require Ca+2 or Mg+2 for their activity. The NTPDases can be differentiated according to their substrate specificity, divalent cation usage and product formation. | + | '''Ectonucleoside triphosphate diphosphohydrolase (NTPDase)''' hydrolyzes nucleoside 5’-triphosphate to nucleoside 5’-phosphate and 2 phosphates. NTPDase can hydrolyze ATP and ADP. NTPDase has an important role in regulating neutrophil chemotaxis. NTPDase 1,2,3,8 are cell surface enzymes with catalytic sites facing extracellularly while other NTPDases act intracellularly. NTPDase require Ca<sup>+2</sup> or Mg<sup>+2</sup> for their activity. The NTPDases can be differentiated according to their substrate specificity, divalent cation usage and product formation. |
== Disease == | == Disease == | ||
Revision as of 10:47, 11 January 2016
| |||||||||||
3D structures of ectonucleoside triphosphate diphosphohydrolase
Updated on 11-January-2016
