Elongation factor

Elongation factors (EF) facilitate translational elongation during the formation of peptide bonds in the ribosome.

• EF-selB is selenocysteine-specific EF.
  
• EF-Tu or EF 1-α (elongation factor thermo unstable) is a prokaryotic EF. EF-Tu contributes to translational accuracy. It catalyzes the addition of aminoacyl tRNA.
  
• EF-Ts or EF 1-β (elongation factor thermo stable) catalyzes the release of GDP from EF-Tu.
  
• EF-G translocates the peptidyl tRNA from the A site to the P site while moving the mRNA through the ribosome.
  
• EF-SII helps RNA polymerase II to bypass blocks to elongation.
  
• EF-ELL2 enhances polyadenylation and exon skipping with the gene encoding the immunoglobulin heavy-chain complex.
  
• EF-GreA or GreB are cleavage factors allowing the resumption of elongation.
  
• EF-NusA recruits translesion DNA polymerases to gaps encountered during translation.
  
• EF-P alters the ribosome affinity to aminoacyl-tRNA.
  
• EF-1 γ acts during the delivery of aminoacyl tRNA to the ribosome.
  
• EF-2 promotes the translocation of the nascent protein chain from the A site to the P site on the ribosome.
  
• EF-3 is a unique EF in fungi hence it provides an anti-fungal drug target.
  
• EF Spt4, Spt5, Spt6 are conserved among eukaryotes. They modulate the chromatin structure.
  
• EF-CA150 is believed to play a role in coupling transcription and splicing.
  
• Elongin B and C complex is involved in the proteasomal degredation of target proteins.
  

For EF-3 see HEAT Repeat
For EF-SelB see SelB.

3D structures of elongation factor

Updated on 29-March-2015