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4yx7
From Proteopedia
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| - | ''' | + | ==Complex of SpaO(SPOA1,2) and OrgB(APAR)::T4lysozyme fusion protein== |
| + | <StructureSection load='4yx7' size='340' side='right' caption='[[4yx7]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4yx7]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YX7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YX7 FirstGlance]. <br> | ||
| + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yx7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yx7 RCSB], [http://www.ebi.ac.uk/pdbsum/4yx7 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SPAO_SALTY SPAO_SALTY]] Involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells. [[http://www.uniprot.org/uniprot/ORGB_SALTY ORGB_SALTY]] Oxygen-regulated protein required for bacterial internalization. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Translocating proteins across the double membrane of Gram-negative bacteria, type III secretion systems (T3SS) occur in two evolutionarily related forms: injectisomes, delivering virulence factors into host cells, and the flagellar system, secreting the polymeric filament used for motility. While both systems share related elements of a cytoplasmic sorting platform that facilitates the hierarchical secretion of protein substrates, its assembly and regulation remain unclear. Here we describe a module mediating the assembly of the sorting platform in both secretion systems, and elucidate the structural basis for segregation of homologous components among these divergent T3SS subtypes sharing a common cytoplasmic milieu. These results provide a foundation for the subtype-specific assembly of T3SS sorting platforms and will support further mechanistic analysis and anti-virulence drug design. | ||
| - | + | A common assembly module in injectisome and flagellar type III secretion sorting platforms.,Notti RQ, Bhattacharya S, Lilic M, Stebbins CE Nat Commun. 2015 May 21;6:7125. doi: 10.1038/ncomms8125. PMID:25994170<ref>PMID:25994170</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Stebbins, C | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Lysozyme]] | ||
| + | [[Category: Notti, R Q]] | ||
| + | [[Category: Stebbins, C E]] | ||
| + | [[Category: Protein transport]] | ||
| + | [[Category: Type iii secretion system]] | ||
Revision as of 12:32, 3 June 2015
Complex of SpaO(SPOA1,2) and OrgB(APAR)::T4lysozyme fusion protein
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