This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4yxm
From Proteopedia
(Difference between revisions)
m (Protected "4yxm" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | ''' | + | ==Structure of Thermotoga maritima DisA D75N mutant with reaction product c-di-AMP== |
| - | + | <StructureSection load='4yxm' size='340' side='right' caption='[[4yxm]], [[Resolution|resolution]] 2.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4yxm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YXM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2BA:(2R,3R,3AS,5R,7AR,9R,10R,10AS,12R,14AR)-2,9-BIS(6-AMINO-9H-PURIN-9-YL)OCTAHYDRO-2H,7H-DIFURO[3,2-D 3,2-J][1,3,7,9,2,8]TETRAOXADIPHOSPHACYCLODODECINE-3,5,10,12-TETROL+5,12-DIOXIDE'>2BA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3c1y|3c1y]], [[3c1z|3c1z]], [[3c21|3c21]], [[3c23|3c23]], [[4yvz|4yvz]], [[4yxj|4yxj]]</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diadenylate_cyclase Diadenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.85 2.7.7.85] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yxm RCSB], [http://www.ebi.ac.uk/pdbsum/4yxm PDBsum]</span></td></tr> |
| - | [[Category: Hopfner, K | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DISA_THEMA DISA_THEMA]] Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity).<ref>PMID:18439896</ref> Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. Does not convert GTP to c-di-GMP.<ref>PMID:18439896</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Diadenylate cyclase]] | ||
| + | [[Category: Deimling, T]] | ||
| + | [[Category: Hopfner, K P]] | ||
[[Category: Mueller, M]] | [[Category: Mueller, M]] | ||
[[Category: Witte, G]] | [[Category: Witte, G]] | ||
| - | [[Category: | + | [[Category: C-di-amp synthesis]] |
| + | [[Category: Dac domain]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Pre-reaction state]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 12:48, 3 June 2015
Structure of Thermotoga maritima DisA D75N mutant with reaction product c-di-AMP
| |||||||||||
