2rjf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 4: Line 4:
|PDB= 2rjf |SIZE=350|CAPTION= <scene name='initialview01'>2rjf</scene>, resolution 2.05&Aring;
|PDB= 2rjf |SIZE=350|CAPTION= <scene name='initialview01'>2rjf</scene>, resolution 2.05&Aring;
|SITE=
|SITE=
-
|LIGAND=
+
|LIGAND= <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= L3MBTL, KIAA0681, L3MBT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= L3MBTL, KIAA0681, L3MBT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
 +
|DOMAIN=
 +
|RELATEDENTRY=[[2pqw|2PQW]], [[2rjc|2RJC]], [[2rjd|2RJD]], [[2rje|2RJE]]
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjf OCA], [http://www.ebi.ac.uk/pdbsum/2rjf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rjf RCSB]</span>
}}
}}
Line 57: Line 60:
[[Category: zinc-finger]]
[[Category: zinc-finger]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:36:45 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:01:10 2008''

Revision as of 02:01, 31 March 2008

Image:2rjf.gif


PDB ID 2rjf

Drag the structure with the mouse to rotate
, resolution 2.05Å
Ligands:
Gene: L3MBTL, KIAA0681, L3MBT (Homo sapiens)
Related: 2PQW, 2RJC, 2RJD, 2RJE


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 12-30), orthorhombic form I


Overview

Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated on Lys20 (H4K20me2) show that only the second of the three MBT repeats can bind mono- and dimethylated histone peptides. Its binding pocket has similarities to that of 53BP1 and is able to recognize the degree of histone lysine methylation. An unexpected mode of peptide-mediated dimerization suggests a possible mechanism for chromatin compaction by L3MBTL1.

About this Structure

2RJF is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

L3MBTL1 recognition of mono- and dimethylated histones., Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y, MacKenzie F, Vedadi M, Arrowsmith CH, Nat Struct Mol Biol. 2007 Dec;14(12):1229-30. Epub 2007 Nov 18. PMID:18026117

Page seeded by OCA on Mon Mar 31 05:01:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2rjf"
Personal tools