Fibronectin

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[[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]]]]
[[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]]]]
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{{STRUCTURE_3m7p| PDB=3m7p | SIZE=400| SCENE= |right|CAPTION=Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) [[3m7p]] }}
 
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<StructureSection load='3m7p' size='350' side='right' scene='' caption='Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code [[3m7p]]) '>
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== Function ==
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[[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion<ref>PMID:12244123</ref>.
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== Relevance ==
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Fn is associated with wound healing. Fn is a potential marker for radiation resistance.
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== Disease ==
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Overexpression of Fn1 is associated with lung cancer.
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== Structural insights ==
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Fn is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD).
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</StructureSection>
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[[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD).
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== 3D Structures of Fibronectin ==
== 3D Structures of Fibronectin ==
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**[[3mql]] – hFn 6FnI+2FnII+7FnI
**[[3mql]] – hFn 6FnI+2FnII+7FnI
}}
}}
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== References ==
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<references/>
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[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 13:54, 22 January 2016

Image:1fbr.png
Crystal Structure of Fibronectin 4-5FnI fragment 1fbr

Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code 3m7p)

Drag the structure with the mouse to rotate

3D Structures of Fibronectin

Updated on 22-January-2016

References

  1. ↑ Pankov R, Yamada KM. Fibronectin at a glance. J Cell Sci. 2002 Oct 15;115(Pt 20):3861-3. PMID:12244123

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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