Galectin
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='1w6o' size='400' side='right' caption='Structure of human galectin-1 complex with lactose (PDB entry [[1hlc]])' scene=''> |
| + | == Function == | ||
| - | '''Galectin''' (GAL) are lectins which bind β-galactosidase (BGAL). GAL contains a carbohydrate recognition domain (CRD). | + | '''Galectin''' (GAL) are lectins which bind β-galactosidase (BGAL). GAL contains a carbohydrate recognition domain (CRD)<ref>PMID:8063692</ref>. <br /> |
* GAL-1 is thought to play a role as autocrine negative growth factor that regulates cell proliferation.<br /> | * GAL-1 is thought to play a role as autocrine negative growth factor that regulates cell proliferation.<br /> | ||
* GAL-2 is expressed primarily in gastrointestinal tract.<br /> | * GAL-2 is expressed primarily in gastrointestinal tract.<br /> | ||
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* GAL-9 affects eosinophil survival. <br /> | * GAL-9 affects eosinophil survival. <br /> | ||
* GAL-10 or Charcot-Leyden crystal protein acts on biological membranes to regulate the multifunctional lysophospholipids. | * GAL-10 or Charcot-Leyden crystal protein acts on biological membranes to regulate the multifunctional lysophospholipids. | ||
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| + | == Relevance == | ||
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| + | GAL are known to inhibit chronic inflammation<ref>PMID:20146714</ref>. GAL-3 has a role in experimental autoimmune encephalomyelitis and melanoma methastasis<ref>PMID:22418727</ref>. | ||
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| + | == Structural highlights == | ||
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| + | The CRD is a β-sandwich long enough to bind a tetrasaccharide. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 11:36, 3 March 2016
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3D structures of galectin
Updated on 03-March-2016
