Sandbox Reserved 1074

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== '''Structure''' ==
== '''Structure''' ==
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Crystal structures of InhA reveal a <scene name='69/694241/Homotetramer_subunits_labeled/1'>homotetramer</scene>. Each <scene name='69/694241/Monomer_subunit_no_ligands/1'>monomer</scene> subunit features a single domain with a central core that supports a <scene name='69/694241/Monomer_subunit/2'>NADH binding site</scene>. The alpha6 and alpha7 helices, composed of the <scene name='69/694241/Monomer_subunit_196_219/1'>amino acid residues 196-219</scene>, make up the substrate binding loop of InhA.
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Crystal structures of InhA reveal a <scene name='69/694241/Homotetramer_subunits_labeled/1'>homotetramer</scene> with separate ligand binding sites in each subunit. Each <scene name='69/694241/Monomer_subunit_no_ligands/1'>monomer</scene> subunit features a single domain with a central core that supports a NADH binding site. The alpha6 and alpha7 helices of the monomer form one side of the fatty acyl substrate binding crevice of InhA. Within this binding crevice, many hydrophobic side chains form the amino acids involved in forming the substrate binding loop, <scene name='69/694241/Monomer_subunit_196_219/1'> residues 196-219</scene>, interact with the substrates. One side of this cavity is open and exposed to solvent, which allows the substrates to access the binding pocket of this enzyme.
<scene name='69/694241/Substrate_binding_pocket/1'>substrate binding pocket</scene>
<scene name='69/694241/Substrate_binding_pocket/1'>substrate binding pocket</scene>
[[Image:Monomer_Publication_Image.png |300 px|left|thumb|<div align="center">InhA Monomer with NAD and 2TK]]
[[Image:Monomer_Publication_Image.png |300 px|left|thumb|<div align="center">InhA Monomer with NAD and 2TK]]
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<scene name='69/694241/Monomer_subunit/2'>NADH binding site</scene>.

Revision as of 02:30, 7 April 2015

This Sandbox is Reserved from 02/09/2015, through 05/31/2016 for use in the course "CH462: Biochemistry 2" taught by Geoffrey C. Hoops at the Butler University. This reservation includes Sandbox Reserved 1051 through Sandbox Reserved 1080.
To get started:
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Enoyl-ACP Reductase InhA from Mycobacterium tuberculosis

Enoyl-ACP Reductase InhA Homotetramer

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References

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