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== Function ==
== Function ==
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The FadD13 enzyme functions to activate lipids before going into metabolic pathways. This is done by ATP/AMP binding to the <scene name='69/694230/Atp_and_amp_binding_region/4'>ATP and AMP binding region</scene>. Once ATP/AMP is bound the long lipid chain up to 26 carbons may bind in the hydrophobic portion of the enzyme. Upon binding of the substrate, the C terminal swings up to close off the tunnel. From There CoA can bind to produce the final product, an acyl-CoA Thioester. The lipid can now move transversely throughout the membrane and throughout the rest of the cell. Below is the proposed mechanism for ACSVL proteins<ref> Andersson, C.S., Lundgren, C.A.K., Magnusdottir, A., Ge, C., Weislander, A., Molina, D., Hogbom, M. (2012)The Mycobacterium tuberculosis Very-Long-Chain Fatty Acyl-CoA Synthetase: structural Basis for Housing lipid Substrates longer than the Enzyme. Cell Press,1062-1070 </ref>.
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The FadD13 enzyme functions to activate lipids before going into metabolic pathways. This is done by ATP/AMP binding to the <scene name='69/694230/Atp_and_amp_binding_region/4'>ATP and AMP binding region</scene>. Once ATP/AMP is bound, the long lipid chain up to 26 carbons may bind in the hydrophobic portion of the enzyme. Upon binding of the substrate, the C terminal swings up to close off the tunnel. From there CoA can bind to produce the final product, an acyl-CoA Thioester. The lipid can now move transversely throughout the membrane and throughout the rest of the cell. Below is the proposed mechanism for ACSVL proteins<ref> Andersson, C.S., Lundgren, C.A.K., Magnusdottir, A., Ge, C., Weislander, A., Molina, D., Hogbom, M. (2012)The Mycobacterium tuberculosis Very-Long-Chain Fatty Acyl-CoA Synthetase: structural Basis for Housing lipid Substrates longer than the Enzyme. Cell Press,1062-1070 </ref>.
[[Image:Proposed Mechanism.png|100 px|thumb|left|Proposed Mechanism]]
[[Image:Proposed Mechanism.png|100 px|thumb|left|Proposed Mechanism]]

Revision as of 04:05, 8 April 2015

FadD13

Caption for this structure

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References

  1. 3R44
  2. Andersson, C.S., Lundgren, C.A.K., Magnusdottir, A., Ge, C., Weislander, A., Molina, D., Hogbom, M. (2012)The Mycobacterium tuberculosis Very-Long-Chain Fatty Acyl-CoA Synthetase: structural Basis for Housing lipid Substrates longer than the Enzyme. Cell Press,1062-1070
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