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4q6s

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'''Unreleased structure'''
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==CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36==
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<StructureSection load='4q6s' size='340' side='right' caption='[[4q6s]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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The entry 4q6s is ON HOLD until Apr 29 2016
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4q6s]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q6S FirstGlance]. <br>
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Authors: Amacher, J.F., Madden, D.R.
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene>, <scene name='pdbligand=DAR:D-ARGININE'>DAR</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jof|4jof]]</td></tr>
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Description: CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q6s RCSB], [http://www.ebi.ac.uk/pdbsum/4q6s PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Amacher, J.F]]
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== Disease ==
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[[Category: Madden, D.R]]
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[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Amacher, J F]]
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[[Category: Madden, D R]]
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[[Category: Pdz-peptide complex]]
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[[Category: Transport protein]]

Revision as of 11:33, 30 April 2015

CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36

4q6s, resolution 1.45Å

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