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4wxv

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'''Unreleased structure'''
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==Human cationic trypsin K97D mutant in complex with bovine pancreatic trypsin inhibitor (BPTI)==
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<StructureSection load='4wxv' size='340' side='right' caption='[[4wxv]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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The entry 4wxv is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4wxv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WXV FirstGlance]. <br>
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Authors: Alloy, A., Kayode, O., Soares, A.S., Wang, R., Radisky, E.S.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
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Description: Human cationic trypsin K97D mutant in complex with bovine pancreatic trypsin inhibitor (BPTI)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wxv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wxv RCSB], [http://www.ebi.ac.uk/pdbsum/4wxv PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Soares, A.S]]
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== Disease ==
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[[http://www.uniprot.org/uniprot/TRY1_HUMAN TRY1_HUMAN]] Defects in PRSS1 are a cause of pancreatitis (PCTT) [MIM:[http://omim.org/entry/167800 167800]]. A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks.<ref>PMID:10930381</ref> <ref>PMID:8841182</ref> <ref>PMID:11866271</ref> <ref>PMID:9322498</ref> <ref>PMID:9633818</ref> <ref>PMID:10381903</ref> <ref>PMID:10204851</ref> <ref>PMID:11073545</ref> <ref>PMID:11788572</ref> <ref>PMID:14695529</ref> <ref>PMID:15776435</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/TRY1_HUMAN TRY1_HUMAN]] Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.<ref>PMID:7945238</ref> [[http://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Trypsin]]
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[[Category: Alloy, A]]
[[Category: Kayode, O]]
[[Category: Kayode, O]]
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[[Category: Radisky, E S]]
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[[Category: Soares, A S]]
[[Category: Wang, R]]
[[Category: Wang, R]]
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[[Category: Alloy, A]]
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[[Category: Bpti]]
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[[Category: Radisky, E.S]]
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[[Category: Trypsin inhibitor]]

Revision as of 14:17, 22 July 2015

Human cationic trypsin K97D mutant in complex with bovine pancreatic trypsin inhibitor (BPTI)

4wxv, resolution 2.10Å

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