Glutaryl-CoA dehydrogenase
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | <StructureSection load='3mpi' size='340' side='right' caption='Structure of glutaryl-CoA dehydrogenase complex with | + | <StructureSection load='3mpi' size='340' side='right' caption='Structure of glutaryl-CoA dehydrogenase complex with FAD and glutaryl-CoA (PDB code [[3mpi]]).' scene=''> |
== Function == | == Function == | ||
| - | '''Glutaryl-CoA dehydrogenase''' (GCD) converts glutaryl-CoA to crotonyl-CoA. GCD is part of the metabolism of lysine and tryptophan. | + | '''Glutaryl-CoA dehydrogenase''' (GCD) converts glutaryl-CoA to crotonyl-CoA. GCD is part of the metabolism of lysine and tryptophan<ref>PMID:17176108</ref>. |
== Disease == | == Disease == | ||
| - | Defective GCD causes the often fatal glutaric acidemia. | + | Defective GCD causes the often fatal glutaric acidemia<ref>PMID:249723495</ref>. |
== Relevance == | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
| + | |||
| + | GCD active site is in a cleft formed by its α,β,α domains<ref>PMID:20486657</ref>. | ||
==3D structures of glutaryl-CoA dehydrogenase== | ==3D structures of glutaryl-CoA dehydrogenase== | ||
Revision as of 08:00, 10 March 2016
| |||||||||||
