Sandbox PgpWWC

P-glycoprotein (P-gp, ABCB1) is an ATP casette transporter that hydrolyses ATP for conformational changes after a variety of substrates are transported. It is one of the membrane proteins responsible for the multi drug resistance (MDR) in cancer treatment, as well as various other drug therapies (Aller et. al 2009; He and Liu 2002). P-gp can be found in tumor cells, as well as in the liver, kidney, adrenal gland, intestine, blood-brain barrier (BBB), placenta, blood-testis barrier, and blood-ovarian barriers. An effective MDR transport protein, the high amount of active Pgp substrates stems from the polyspecificity for hydrophobic and aromatic compounds (Marchetti, Mazzanti, Beijnen, & Schellens 2007).

Function

Disease

Relevance

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.