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Heat Shock Proteins

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Line 1: Line 1:
{{STRUCTURE_3los| PDB=3los | SIZE=400| SCENE= |right|CAPTION=Hsp60 from ''Methanococcus maripaludis '' [[3los]] }}
{{STRUCTURE_3los| PDB=3los | SIZE=400| SCENE= |right|CAPTION=Hsp60 from ''Methanococcus maripaludis '' [[3los]] }}
-
[[Heat Shock Proteins]] (Hsp). The Hsp are proteins which are expressed when cells are exposed to stresses like heat. Hsp60, Hsp70, Hsp90 etc. are named according to their molecular weights. Their function is to provide protection from stress.
+
[[Heat Shock Proteins]] (Hsp). The Hsp are proteins which are expressed when cells are exposed to stresses like heat. Hsp60, Hsp70, Hsp90 etc. are named according to their molecular weights. Their function is to provide protection from stress. Hsp contains a nucleotide-binding domain (NBD), a substrate-binding domain (sub) and C-terminal lid domain (lid). In E. coli there are additional Hsp – HslV (19kD), HslJ and HslU (50kD). The heat-inducible Hsp is called '''heat shock cognate protein''' (Hsc).
See also<br />
See also<br />
* [[Chaperones]]<br />
* [[Chaperones]]<br />
Line 16: Line 16:
*Small Hsp
*Small Hsp
-
**[[1shs]], [[4eld]] – Hsp – ''Methanococcus jannaschii''<br />
+
**[[1shs]], [[4eld]], [[4i88]] – Hsp – ''Methanococcus jannaschii''<br />
-
**[[1gme]] – Hsp 17kD – wheat<br />
+
**[[1gme]] – wHsp 17kD – wheat<br />
 +
**[[2byu]] - wHsp 17kD – Cryo EM<br />
**[[2bol]] – Hsp – ''Taenia saginata''<br />
**[[2bol]] – Hsp – ''Taenia saginata''<br />
**[[2h50]], [[2h53]] – yHsp26 – yeast<br />
**[[2h50]], [[2h53]] – yHsp26 – yeast<br />
Line 35: Line 36:
**[[1hw7]], [[3m7m]] – EcHsp33 N-terminal <br />
**[[1hw7]], [[3m7m]] – EcHsp33 N-terminal <br />
**[[1i7f]] – EcHsp33 chaperone domain (mutant)<br />
**[[1i7f]] – EcHsp33 chaperone domain (mutant)<br />
-
**[[1xjh]] - EcHsp33 C-terminal - NMR<br />
+
**[[1xjh]] - EcHsp33 lid - NMR<br />
**[[1vq0]] – Hsp33 – ''Thermotoga maritima''<br />
**[[1vq0]] – Hsp33 – ''Thermotoga maritima''<br />
**[[1vzy]] – Hsp33 – ''Bacillus subtilis''
**[[1vzy]] – Hsp33 – ''Bacillus subtilis''
Line 51: Line 52:
**[[2qld]] – hHsp40<br />
**[[2qld]] – hHsp40<br />
**[[1hdj]] – hHsp40 J domain - NMR
**[[1hdj]] – hHsp40 J domain - NMR
 +
 +
*Hsp47
 +
 +
**[[3zha]] – dHsp47 + collagen peptide - dog<br />
* Hsp60 - the large subunit of the chaperonin molecule GroEL
* Hsp60 - the large subunit of the chaperonin molecule GroEL
Line 73: Line 78:
**[[3a8y]] – hHsp70 NBD+BAG domain regulator protein – human<br />
**[[3a8y]] – hHsp70 NBD+BAG domain regulator protein – human<br />
-
**[[3fzf]] - hHsp70 NBD+BAG domain regulator protein+ATP<br />
+
**[[4io8]] - hHsp70 NBD + inhibitor<br />
-
**[[3fzh]], [[3fzm]], [[3ldq]], [[3m3z]] - hHsp70 NBD+BAG domain regulator protein+ adenosine derivative<br />
+
-
**[[3fzk]], [[3fzl]] - hHsp70 NBD+BAG domain regulator protein+ purine derivative<br />
+
-
**[[3cqx]] - Hsp70 NBD+BAG domain regulator protein – mouse<br />
+
**[[3lof]] – hHsp70 lid<br />
**[[3lof]] – hHsp70 lid<br />
-
**[[2lmg]] – hHsp70 C terminal - NMR<br />
+
**[[4po2]] - hHsp70 lid + peptide<br />
 +
**[[2lmg]] – hHsp70 lid - NMR<br />
**[[1xqs]] – hHsp70 sub + Hsp-binding protein core domain<br />
**[[1xqs]] – hHsp70 sub + Hsp-binding protein core domain<br />
**[[2p32]] - CeHsp70 lid<br />
**[[2p32]] - CeHsp70 lid<br />
Line 86: Line 89:
**[[3jxu]], [[3i33]], [[3gdq]], [[3fe1]] - hHsp70 NBD+ADP+P<br />
**[[3jxu]], [[3i33]], [[3gdq]], [[3fe1]] - hHsp70 NBD+ADP+P<br />
**[[3iuc]], [[3atu]], [[3atv]], [[3ay9]] - hHsp70 NBD+ADP<br />
**[[3iuc]], [[3atu]], [[3atv]], [[3ay9]] - hHsp70 NBD+ADP<br />
-
**[[4j8f]] - hHsp70 NBD/HIP middle domain<br />
+
**[[4j8f]], [[4wv5]] - hHsp70 sub domain<br />
 +
**[[4wv7]] - hHsp70 sub domain + novolactone<br />
**[[2e88]], [[1s3x]], [[1hjo]] - hHsp70 NBD<br />
**[[2e88]], [[1s3x]], [[1hjo]] - hHsp70 NBD<br />
**[[2e8a]] - hHsp70 NBD+AMPPNP<br />
**[[2e8a]] - hHsp70 NBD+AMPPNP<br />
-
**[[2qw9]] – bHsp70 NBD – bovine<br />
 
-
**[[2bup]], [[1bup]], [[1qqm]], [[1qqn]] - bHsp70 NBD (mutant)<br />
 
-
**[[2qwl]], [[2qwm]], [[1atr]], [[1ats]], [[1hpm]], [[1nga]], [[1ngb]], [[1ngc]], [[1ngd]], [[3hsc]] - bHsp70 NBD+ADP<br />
 
-
**[[1qqo]] – bHsp70 (mutant)<br />
 
-
**[[2qwn]], [[2qwo]], [[2qwp]], [[2qwq]], [[2qwr]] - bHsp70 NBD (mutant)+ auxilin protein<br />
 
-
**[[1ba0]], [[1ba1]] – bHsp70 NBD (mutant) + ADP<br />
 
-
**[[1kax]], [[1kay]], [[1kaz]] - bHsp70 NBD (mutant) + ATP<br />
 
-
**[[1nge]], [[1ngf]], [[1ngg]], [[1ngh]] - bHsp70 NBD + ATP<br />
 
-
**[[1ngi]], [[1ngj]] - bHsp70 NBD + phosphoaminophosphonic acid<br />
 
**[[1hx1]] - bHsp70 NBD + molecular chaperone regulator 1 BAG domain<br />
**[[1hx1]] - bHsp70 NBD + molecular chaperone regulator 1 BAG domain<br />
**[[2kho]] – EcHsp70 – ''Escherichia coli'' – NMR<br />
**[[2kho]] – EcHsp70 – ''Escherichia coli'' – NMR<br />
-
**[[1q5l]] - EcHsp70 sub domain+peptide - NMR<br />
+
**[[1q5l]] - EcHsp70 sub +peptide - NMR<br />
**[[3gl1]] - ScHsp70 NBD – ''Saccharomyces cerevisiae''<br />
**[[3gl1]] - ScHsp70 NBD – ''Saccharomyces cerevisiae''<br />
**[[3dpo]] – EcHsp70 sub+12-mer peptide<br />
**[[3dpo]] – EcHsp70 sub+12-mer peptide<br />
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**[[4i2w]] – CeHsp70 + myosin chaperone<br />
**[[4i2w]] – CeHsp70 + myosin chaperone<br />
**[[2d2e]], [[3d2f]] – ScHsp70 NBD+SSE1(Hsp110)<br />
**[[2d2e]], [[3d2f]] – ScHsp70 NBD+SSE1(Hsp110)<br />
-
**[[2v7z]] – rHsp70 NBD+sub – rat<br />
 
-
**[[7hsc]], [[1ckr]] - rHsp70 sub - NMR<br />
 
-
**[[3lca]] – yHsp70 Ssa1 C-terminal+yTOM71<br />
 
**[[2v7y]] – Hsp70 NBD+sub – ''Geobacillus kaustophilus''
**[[2v7y]] – Hsp70 NBD+sub – ''Geobacillus kaustophilus''
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**[[3r91]] - hHsp90 NTD (mutant) +indole derivative<br />
**[[3r91]] - hHsp90 NTD (mutant) +indole derivative<br />
**[[3hhu]], [[4jql]] - hHsp90 NTD+ carbamic acid derivative<br />
**[[3hhu]], [[4jql]] - hHsp90 NTD+ carbamic acid derivative<br />
-
**[[3ft8]], [[3ft5]] - hHsp90 NTD+quinazoline derivative<br />
+
**[[3ft8]], [[3ft5]], [[4cwf]], [[4cwn]], [[4cwo]], [[4cwp]], [[4cwq]], [[4cwr]], [[4cws]], [[4cwt]] - hHsp90 NTD+quinazoline derivative inhibitor<br />
**[[2k5b]] - hHsp90 NTD+Cdc37 – NMR - docking<br />
**[[2k5b]] - hHsp90 NTD+Cdc37 – NMR - docking<br />
**[[3eko]], [[3ekr]] - hHsp90 NTD+dihydroxyphenyl amide<br />
**[[3eko]], [[3ekr]] - hHsp90 NTD+dihydroxyphenyl amide<br />
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**[[4hy6]] - hHsp90 NTD + indazole derivative<br />
**[[4hy6]] - hHsp90 NTD + indazole derivative<br />
**[[2qg2]], [[2cvi]], [[2cvj]], [[2uwd]], [[4b7p]] - hHsp90 NTD+oxazole derivative<br />
**[[2qg2]], [[2cvi]], [[2cvj]], [[2uwd]], [[4b7p]] - hHsp90 NTD+oxazole derivative<br />
-
**[[3d0b]], [[3rkz]] - hHsp90 NTD+benzamide derivative<br />
+
**[[3d0b]], [[3rkz]], [[3wq9]] - hHsp90 NTD+benzamide derivative<br />
**[[3inw]], [[3inx]] - hHsp90 NTD+pochoxime derivative<br />
**[[3inw]], [[3inx]] - hHsp90 NTD+pochoxime derivative<br />
-
**[[2fwy]], [[2fwz]], [[2h55]], [[1uym]], [[3o0l]] - hHsp90 NTD+PU inhibitor<br />
+
**[[2fwy]], [[2fwz]], [[2h55]], [[1uym]], [[3o0i]] - hHsp90 NTD+PU inhibitor<br />
**[[2ccs]], [[2cct]], [[2ccu]], [[2cdd]], [[2byh]], [[2byi]], [[2bsm]], [[2bt0]], [[1yc3]], [[1yc1]], [[1yc4]] - hHsp90 NTD+pyrazol derivative<br />
**[[2ccs]], [[2cct]], [[2ccu]], [[2cdd]], [[2byh]], [[2byi]], [[2bsm]], [[2bt0]], [[1yc3]], [[1yc1]], [[1yc4]] - hHsp90 NTD+pyrazol derivative<br />
-
**[[2ye2]], [[2ye3]], [[2ye4]], [[2ye5]], [[2ye6]], [[2ye7]], [[2ye8]], [[2ye9]], [[2yea]], [[2yeb]], [[2yec]], [[2yed]], [[2yee]], [[2yef]], [[2yeg]], [[2yeh]], [[2yei]], [[2yej]], [[2yjw]], [[2yjx]], [[2yk2]], [[2yk9]], [[2ykb]], [[2ykc]], [[2yke]], [[2yki]], [[2ykj]], [[3ow6]], [[3owb]], [[3owd]], [[3qdd]], [[3tuh]], [[3vha]], [[3vhc]], [[3vhd]], [[4awo]], [[4awp]], [[4awq]], [[4eeh]], [[4eft]], [[4efu]], [[4egh]], [[4egi]], [[4egk]], [[4fcp]], [[4fcq]], [[4fcr]]- hHsp90 NTD + inhibitor<br />
+
**[[2ye2]], [[2ye3]], [[2ye4]], [[2ye5]], [[2ye6]], [[2ye7]], [[2ye8]], [[2ye9]], [[2yea]], [[2yeb]], [[2yec]], [[2yed]], [[2yee]], [[2yef]], [[2yeg]], [[2yeh]], [[2yei]], [[2yej]], [[2yjw]], [[2yjx]], [[2yk2]], [[2yk9]], [[2ykb]], [[2ykc]], [[2yke]], [[2yki]], [[2ykj]], [[3ow6]], [[3owb]], [[3owd]], [[3qdd]], [[3tuh]], [[3vha]], [[3vhc]], [[3vhd]], [[4awo]], [[4awp]], [[4awq]], [[4eeh]], [[4eft]], [[4efu]], [[4egh]], [[4egi]], [[4egk]], [[4fcp]], [[4fcq]], [[4fcr]], [[3wha]], [[4bqg]], [[4bqj]], [[4l8z]], [[4l90]], [[4l91]], [[4l93]], [[4lwe]], [[4l94]], [[4lwf]], [[4lwg]], [[4lwh]], [[4lwi]], [[4nh7]], [[4nh8]], [[4o04]], [[4o05]], [[4o07]], [[4o09]], [[4o0b]], [[4r3m]], [[4u93]], [[4w7t]], [[4xip]], [[4xiq]], [[4xir]], [[4xit]] - hHsp90 NTD + inhibitor<br />
**[[1byq]] - hHsp90 NTD+ATP-Mg<br />
**[[1byq]] - hHsp90 NTD+ATP-Mg<br />
 +
**[[2qf6]] - hHsp90 NTD + antigen<br />
**[[2xhr]], [[2xht]], [[2xhx]], [[2xjg]], [[2xjj]], [[2xjx]], [[2xk2]], [[2xdx]], [[2xdu]], [[2xds]], [[2xdl]], [[2xdk]], [[2xab]], [[2vcj]], [[2vci]], [[3hyy]], [[3hyz]], [[3hz1]], [[3hz5]], [[3mnr]] - hHsp90 NTD+ antigen<br />
**[[2xhr]], [[2xht]], [[2xhx]], [[2xjg]], [[2xjj]], [[2xjx]], [[2xk2]], [[2xdx]], [[2xdu]], [[2xds]], [[2xdl]], [[2xdk]], [[2xab]], [[2vcj]], [[2vci]], [[3hyy]], [[3hyz]], [[3hz1]], [[3hz5]], [[3mnr]] - hHsp90 NTD+ antigen<br />
**[[2brc]], [[2bre]], [[1am1]] - yHsp90 NTD+pyrazol derivative<br />
**[[2brc]], [[2bre]], [[1am1]] - yHsp90 NTD+pyrazol derivative<br />
Line 153: Line 146:
**[[3k60]] - PfHsp90 NTD+ADP<br />
**[[3k60]] - PfHsp90 NTD+ADP<br />
**[[2jki]] - Hsp90 NTD+SGT1 domain protein – barley<br />
**[[2jki]] - Hsp90 NTD+SGT1 domain protein – barley<br />
-
**[[2h8m]], [[2hch]] – dHsp90 NTD – dog<br />
+
**[[2h8m]], [[2hch]] – dHsp90 NTD <br />
**[[2hg1]] - dHsp90 NTD+ligand<br />
**[[2hg1]] - dHsp90 NTD+ligand<br />
**[[2xcm]] – Hsp90 NTD+CGT1+RAR1 – ''Hordum vulgare''<br />
**[[2xcm]] – Hsp90 NTD+CGT1+RAR1 – ''Hordum vulgare''<br />
Line 193: Line 186:
**[[1ah6]], [[1ah8]] – yHsp82 NTD1ah6, 1ah8 – yHsp82 NTD<br />
**[[1ah6]], [[1ah8]] – yHsp82 NTD1ah6, 1ah8 – yHsp82 NTD<br />
-
**[[2xd6]] - yHsp82 NTD+macrolactone<br />
+
**[[2xd6]], [[2xx2]], [[2xx4]], [[2xx5]], [[4ce1]], [[4ce2]], [[4ce3]] - yHsp82 NTD+macrolactone<br />
**[[2wep]] – yHsp82 NTD (mutant)+ADP<br />
**[[2wep]] – yHsp82 NTD (mutant)+ADP<br />
-
**[[2akp]] - yHsp82 NTD (mutant)<br />
+
**[[2akp]], [[3c0e]] - yHsp82 NTD (mutant)<br />
-
**[[1weq]], [[3c11]] - yHsp82 NTD (mutant)+ geldamycin<br />
+
**[[1weq]], [[3c11]], [[2yga]], [[2wer]], [[2yge]], [[2ygf]] - yHsp82 NTD (mutant)+ antibiotic<br />
-
**[[2wer]] - yHsp82 NTD (mutant)+radicicol<br />
+
**[[2iws]], [[2iwu]], [[2iwx]], [[2cgf]], 1bgq, [[2fxs]], [[4as9]], [[4asa]], [[4asb]], [[4asf]], [[4asg]] - yHsp82 NTD +antibiotic<br />
-
**[[1bgq]] - yHsp82 NTD +radicicol<br />
+
-
**[[2iws]], [[2iwu]], [[2iwx]], [[2cgf]] - yHsp82 NTD +radicicol analogues<br />
+
**[[2vw5]], [[2vwc]] - yHsp82 NTD +7-o-carbamoylpremacbecin<br />
**[[2vw5]], [[2vwc]] - yHsp82 NTD +7-o-carbamoylpremacbecin<br />
-
**[[3c0e]] - yHsp82 NTD (mutant)<br />
 
**[[2fxs]] - yHsp82 NTD +radamide<br />
**[[2fxs]] - yHsp82 NTD +radamide<br />
**[[1zw9]] - yHsp82 NTD + adenine derivative<br />
**[[1zw9]] - yHsp82 NTD + adenine derivative<br />
Line 216: Line 206:
**[[1r6b]], [[1ksf]] – EcClpA (mutant) <br />
**[[1r6b]], [[1ksf]] – EcClpA (mutant) <br />
 +
**[[4ciu]] - EcClpB (mutant)<br />
 +
**[[4d2u]], [[4d2x]] - EcClpB – Cryo EM<br />
**[[1khy]] – EcClpB NTD <br />
**[[1khy]] – EcClpB NTD <br />
**[[1jbk]] – EcClpB NBD<br />
**[[1jbk]] – EcClpB NBD<br />
-
**[[1k6k]] - EcClpA NTD
+
**[[1k6k]] - EcClpA NTD<br />
 +
**[[4iod]], [[4irf]] - PfClpB <br />
* Hsp110 in mammals is named Sse1, Sse2 in yeast
* Hsp110 in mammals is named Sse1, Sse2 in yeast
-
**[[3d2e]], [[3d2f]], [[3c7n]] – ySse1+Hsp70 <br />
+
**[[3d2e]], [[3d2f]], [[3c7n]] – ySse1+Hsc70 <br />
**[[2qxl]] – ySse1<br />
**[[2qxl]] – ySse1<br />
**[[2llv]] – ySti1 domain 1 – NMR<br />
**[[2llv]] – ySti1 domain 1 – NMR<br />
**[[2llw]] – ySti1 domain 2 – NMR<br />
**[[2llw]] – ySti1 domain 2 – NMR<br />
**[[3upv]] – ySti1 TPR repeats 7-9 + ySse1 peptide<br />
**[[3upv]] – ySti1 TPR repeats 7-9 + ySse1 peptide<br />
-
**[[3uq3]] - ySti1 TPR repeats 4-9 + peptide
+
**[[3uq3]] - ySti1 TPR repeats 4-9 + peptide<br />
 +
**[[3lca]] – ySsa1 lid +yTOM71<br />
 +
 
 +
*Heat shock cognate protein (Hsc)
 +
 
 +
**''Hsc70''
 +
 
 +
**[[3fzf]] - hHsc70 NBD+BAG domain regulator protein+ATP<br />
 +
**[[3fzh]], [[3fzm]], [[3ldq]], [[3m3z]] - hHsc70 NBD+BAG domain regulator protein+ adenosine derivative<br />
 +
**[[3fzk]], [[3fzl]] - hHsc70 NBD+BAG domain regulator protein+ purine derivative<br />
 +
**[[3cqx]] - Hsc70 NBD+BAG domain regulator protein – mouse<br />
 +
**[[2qw9]] – bHsc70 NBD – bovine<br />
 +
**[[2bup]], [[1bup]], [[1qqm]], [[1qqn]], [[1qqo]] - bHsc70 NBD (mutant)<br />
 +
**[[4fl9]], [[1yuw]] - bHsp70 NBD+sub<br />
 +
**[[2qwl]], [[2qwm]], [[1atr]], [[1ats]], [[1hpm]], [[1nga]], [[1ngb]], [[1ngc]], [[1ngd]], [[3hsc]] - bHsc70 NBD+ADP<br />
 +
**[[2qwn]], [[2qwo]], [[2qwp]], [[2qwq]], [[2qwr]] - bHsc70 NBD (mutant)+ auxilin protein<br />
 +
**[[1ba0]], [[1ba1]] – bHsc70 NBD (mutant) + ADP<br />
 +
**[[1kax]], [[1kay]], [[1kaz]] - bHsc70 NBD (mutant) + ATP<br />
 +
**[[1nge]], [[1ngf]], [[1ngg]], [[1ngh]] - bHsc70 NBD + ATP<br />
 +
**[[1ngi]], [[1ngj]] - bHsc70 NBD + phosphoaminophosphonic acid<br />
 +
**[[1hx1]] - bHsc70 NBD + molecular chaperone regulator 1 BAG domain<br />
 +
**[[2v7z]] – rHsc70 NBD+sub – rat<br />
 +
**[[7hsc]], [[1ckr]] - rHsc70 sub - NMR<br />
 +
 
 +
**''Hsc90''
 +
 
 +
**[[4xkk]] – Hsc90 NTD – slime mold<br />
 +
 
 +
 
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:18, 15 April 2015

Template:STRUCTURE 3los

Heat Shock Proteins (Hsp). The Hsp are proteins which are expressed when cells are exposed to stresses like heat. Hsp60, Hsp70, Hsp90 etc. are named according to their molecular weights. Their function is to provide protection from stress. Hsp contains a nucleotide-binding domain (NBD), a substrate-binding domain (sub) and C-terminal lid domain (lid). In E. coli there are additional Hsp – HslV (19kD), HslJ and HslU (50kD). The heat-inducible Hsp is called heat shock cognate protein (Hsc). See also

3D Structures of Heat Shock Proteins

Updated on 15-April-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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