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2n1b
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR solution structure of nucleotide-free Ran GTPase== | |
| - | + | <StructureSection load='2n1b' size='340' side='right' caption='[[2n1b]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2n1b]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N1B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N1B FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n1b OCA], [http://pdbe.org/2n1b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n1b RCSB], [http://www.ebi.ac.uk/pdbsum/2n1b PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[Category: Bacot-Davis, V | + | == Function == |
| - | [[Category: Palmenberg, A | + | [[http://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bacot-Davis, V R]] | ||
| + | [[Category: Palmenberg, A C]] | ||
| + | [[Category: G protein]] | ||
| + | [[Category: Gtp-binding]] | ||
| + | [[Category: Nucleotide-binding]] | ||
| + | [[Category: Nucleus]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 18:36, 12 May 2016
NMR solution structure of nucleotide-free Ran GTPase
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