2v0x

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|PDB= 2v0x |SIZE=350|CAPTION= <scene name='initialview01'>2v0x</scene>, resolution 2.2&Aring;
|PDB= 2v0x |SIZE=350|CAPTION= <scene name='initialview01'>2v0x</scene>, resolution 2.2&Aring;
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0x OCA], [http://www.ebi.ac.uk/pdbsum/2v0x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v0x RCSB]</span>
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[[Category: phosphorylation]]
[[Category: phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:42:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:07:14 2008''

Revision as of 02:07, 31 March 2008

Image:2v0x.gif


PDB ID 2v0x

Drag the structure with the mouse to rotate
, resolution 2.2Å
Ligands:
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



THE DIMERIZATION DOMAIN OF LAP2ALPHA


Overview

Lamina-associated polypeptides (LAPs) are important components of the nuclear lamina, the dense network of filaments that supports the nuclear envelope and also extends into the nucleoplasm. The main protein constituents of the nuclear lamina are the constitutively expressed B-type lamins and the developmentally regulated A- and C-type lamins. LAP2alpha is the only non-membrane-associated member of the LAP family. It preferentially binds lamin A/C, has been implicated in cell-cycle regulation and chromatin organization, and has also been found to be a component of retroviral preintegration complexes. As an approach to understanding the role of LAP2alpha in cellular pathways, we have determined the crystal structure of the C-terminal domain of LAP2alpha, residues 459-693. The C-terminal domain is dimeric and possesses an extensive four-stranded, antiparallel coiled coil. The surface involved in binding lamin A/C is proposed based on results from alanine-scanning mutagenesis and a solid-phase overlay binding assay.

About this Structure

2V0X is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for dimerization of LAP2alpha, a component of the nuclear lamina., Bradley CM, Jones S, Huang Y, Suzuki Y, Kvaratskhelia M, Hickman AB, Craigie R, Dyda F, Structure. 2007 Jun;15(6):643-53. PMID:17562312

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