Sandbox Reserved 978
From Proteopedia
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==Thioredoxin Reductase== | ==Thioredoxin Reductase== | ||
| - | With structure varying slightly between the likes of bacteria, archaea, and other animals, the action of Thioredoxin | + | With structure varying slightly between the likes of bacteria, archaea, and other animals, the action of the family of Thioredoxin Reductases (TrxR) remain the same. TrxR is utilized in the regulation of DNA translation and in apoptosis. Each member of the TrxR family has a different way to program the cell for death. These methods range from marking a protein with an extra amino acid to the reduction of H¬2O2 |
<StructureSection load='2zbw' size='340' side='right' caption='Thioredoxin Reductase=''> | <StructureSection load='2zbw' size='340' side='right' caption='Thioredoxin Reductase=''> | ||
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
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== Function == | == Function == | ||
The protein TrxR is utilized in the regulation of DNA translation and in apoptosis. A normal stop codon (UGA, UAA, and UAG) stops the translation of the mRNA, but in the presence of TrxR an extra Selenocysteine is added to the end of the protein chain. This extra amino acid is what marks the structure for death inside the cell. Enough of these structures in the cell and the entire cell will undergo apoptosis. | The protein TrxR is utilized in the regulation of DNA translation and in apoptosis. A normal stop codon (UGA, UAA, and UAG) stops the translation of the mRNA, but in the presence of TrxR an extra Selenocysteine is added to the end of the protein chain. This extra amino acid is what marks the structure for death inside the cell. Enough of these structures in the cell and the entire cell will undergo apoptosis. | ||
| + | Another function of the TrxR | ||
== Disease == | == Disease == | ||
When left unregulated cell death does not perform as functioned resulting in a build-up of tissue and most often the cause of tumorous growths in the body. This includes cancerous growths as well as non-cancerous. | When left unregulated cell death does not perform as functioned resulting in a build-up of tissue and most often the cause of tumorous growths in the body. This includes cancerous growths as well as non-cancerous. | ||
Revision as of 13:29, 23 April 2015
| This Sandbox is Reserved from 15-Jan-2015, through 30-May-2015 for use in the course "Biochemistry" taught by Jason Telford at the Maryville University. This reservation includes Sandbox Reserved 977 through Sandbox Reserved 986. |
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Thioredoxin Reductase
With structure varying slightly between the likes of bacteria, archaea, and other animals, the action of the family of Thioredoxin Reductases (TrxR) remain the same. TrxR is utilized in the regulation of DNA translation and in apoptosis. Each member of the TrxR family has a different way to program the cell for death. These methods range from marking a protein with an extra amino acid to the reduction of H¬2O2
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
