4ui1
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of the human RGMC-BMP2 complex== |
| - | + | <StructureSection load='4ui1' size='340' side='right' caption='[[4ui1]], [[Resolution|resolution]] 2.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ui1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UI1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uhy|4uhy]], [[4uhz|4uhz]], [[4ui0|4ui0]], [[4ui2|4ui2]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ui1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ui1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ui1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ui1 PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Disease == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/RGMC_HUMAN RGMC_HUMAN]] Hemochromatosis type 2. The disease is caused by mutations affecting the gene represented in this entry. |
| - | [[Category: Bell, C | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN]] Induces cartilage and bone formation. [[http://www.uniprot.org/uniprot/RGMC_HUMAN RGMC_HUMAN]] Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.[UniProtKB:Q7TQ32] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bell, C H]] | ||
[[Category: Bishop, B]] | [[Category: Bishop, B]] | ||
[[Category: Elegheert, J]] | [[Category: Elegheert, J]] | ||
| + | [[Category: Healey, E G]] | ||
| + | [[Category: Padilla-Parra, S]] | ||
[[Category: Siebold, C]] | [[Category: Siebold, C]] | ||
| + | [[Category: Axon guidance]] | ||
| + | [[Category: Bone morphogenetic protein pathway]] | ||
| + | [[Category: Cell surface receptor signaling]] | ||
| + | [[Category: Hemojuvelin]] | ||
| + | [[Category: Morphogen]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 12:59, 6 May 2015
Crystal structure of the human RGMC-BMP2 complex
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